• Gene id: 245711

Gene Summary

• Gene Symbol: SPDYA   Gene   UCSC   Ensembl
• Aliases: RINGO3, RINGOA, SPDY1, SPY1
• Gene name: speedy/RINGO cell cycle regulator family member A
• Alternate names: speedy protein A, RINGO A, epididymis secretory sperm binding protein, hSpy/Ringo A, rapid inducer of G2/M progression in oocytes A, speedy homolog A, speedy-1,
• Gene location: 2p23.2 (28810833: 28850609)     Exons: 8     NC_000002.12
• OMIM: 618689

Protein Summary

• Protein general information: Q5MJ70  
  • Name: Speedy protein A (Rapid inducer of G2/M progression in oocytes A) (RINGO A) (hSpy/Ringo A) (Speedy 1) (Spy1)
  • Length: 313  
  • Mass: 36463
  • Tissue specificity: Highly expressed in testis. Expressed at a low level in wide range of tissues including bone marrow, brain, heart, kidney, colon, liver, placenta, spleen, skeletal muscle, salivary gland, thyroid gland, thymus, trachea and uterus. Expr
• Sequence:

  MRHNQMCCETPPTVTVYVKSGSNRSHQPKKPITLKRPICKDNWQAFEKNTHNNNKSKRPKGPCLVIQRQDMTAFF
  KLFDDDLIQDFLWMDCCCKIADKYLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDEEETKYEIFPWALG
  KNWRKLFPNFLKLRDQLWDRIDYRAIVSRRCCEEVMAIAPTHYIWQRERSVHHSGAVRNYNRDEVQLPRGPSATP
  VDCSLCGKKRRYVRLGLSSSSSLSSHTAGVTEKHSQDSYNSLSMDIIGDPSQAYTGSEVVNDHQSNKGKKTNFLK
  KDKSMEWFTGSEE

• Structural information:
  • Interpro: IPR020984  
  • PDB: 5UQ1 5UQ2 5UQ3
  • PDBsum: 5UQ1 5UQ2 5UQ3
  • STRING: ENSP00000335628
• Other Databases: GeneCards:  SPDYA  Malacards:  SPDYA

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000082	G1/S transition of mitotic cell cycle	IBA	biological process
GO:0005654	nucleoplasm	IBA	cellular component
GO:0008284	positive regulation of cell population proliferation	IBA	biological process
GO:0019901	protein kinase binding	IBA	molecular function
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	biological process
GO:0030295	protein kinase activator activity	IDA	molecular function
GO:0045860	positive regulation of protein kinase activity	IDA	biological process
GO:0007140	male meiotic nuclear division	ISS	biological process
GO:0019901	protein kinase binding	IPI	molecular function
GO:0007275	multicellular organism development	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0007049	cell cycle	IEA	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007140	male meiotic nuclear division	IEA	biological process
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	IEA	biological process
GO:0019901	protein kinase binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0032147	activation of protein kinase activity	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0008284	positive regulation of cell population proliferation	IDA	biological process
GO:0000082	G1/S transition of mitotic cell cycle	IDA	biological process
GO:0019901	protein kinase binding	IPI	molecular function
GO:0019901	protein kinase binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04114	Oocyte meiosis
hsa04914	Progesterone-mediated oocyte maturation

Diseases

Associated diseases	References
Crucial for meiosis during spermatogenesis in R. norvegicus	MIK: 20036869
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)