• Gene id: 23729

Gene Summary

• Gene Symbol: SHPK   Gene   UCSC   Ensembl
• Aliases: CARKL, SHK
• Gene name: sedoheptulokinase
• Alternate names: sedoheptulokinase, carbohydrate kinase-like protein,
• Gene location: 17p13.2 (3636249: 3608239)     Exons: 5     NC_000017.11
• Gene summary(Entrez): The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene
• OMIM: 605060

Protein Summary

• Protein general information: Q9UHJ6  
  • Name: Sedoheptulokinase (SHK) (EC 2.7.1.14) (Carbohydrate kinase like protein)
  • Length: 478  
  • Mass: 51491
  • Tissue specificity: Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain. {ECO
• Sequence:

  MAARPITLGIDLGTTSVKAALLRAAPDDPSGFAVLASCARAARAEAAVESAVAGPQGREQDVSRILQALHECLAA
  LPRPQLRSVVGIGVSGQMHGVVFWKTGQGCEWTEGGITPVFEPRAVSHLVTWQDGRCSSEFLASLPQPKSHLSVA
  TGFGCATIFWLLKYRPEFLKSYDAAGTIHDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNVETLRSSGFPVH
  LLPDIAEPGSVAGRTSHMWFEIPKGTQVGVALGDLQASVYSCMAQRTDAVLNISTSVQLAASMPSGFQPAQTPDP
  TAPVAYFPYFNRTYLGVAASLNGGNVLATFVHMLVQWMADLGLEVEESTVYSRMIQAAVQQRDTHLTITPTVLGE
  RHLPDQLASVTRISSSDLSLGHVTRALCRGIVQNLHSMLPIQQLQDWGVERVMGSGSALSRNDVLKQEVQRAFPL
  PMSFGQDVDAAVGAALVMLRRHLNQKES

• Structural information:
  • Interpro: IPR018484  IPR042027  
  • CDD: cd07777
  • STRING: ENSP00000225519
• Other Databases: GeneCards:  SHPK  Malacards:  SHPK

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005829	cytosol	IBA	cellular component
GO:0071222	cellular response to lipopolysaccharide	IBA	biological process
GO:0016310	phosphorylation	IBA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IBA	molecular function
GO:0050277	sedoheptulokinase activity	IBA	molecular function
GO:0071222	cellular response to lipopolysaccharide	IDA	biological process
GO:0005975	carbohydrate metabolic process	IDA	biological process
GO:0050277	sedoheptulokinase activity	IDA	molecular function
GO:0016310	phosphorylation	IDA	biological process
GO:0050727	regulation of inflammatory response	ISS	biological process
GO:0035963	cellular response to interleukin-13	ISS	biological process
GO:0009052	pentose-phosphate shunt, non-oxidative branch	ISS	biological process
GO:0071353	cellular response to interleukin-4	ISS	biological process
GO:0043030	regulation of macrophage activation	ISS	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	molecular function
GO:0050277	sedoheptulokinase activity	IEA	molecular function
GO:0016301	kinase activity	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0016310	phosphorylation	IEA	biological process
GO:0005524	ATP binding	IEA	molecular function
GO:0005975	carbohydrate metabolic process	TAS	biological process
GO:0050277	sedoheptulokinase activity	IEA	molecular function
GO:0050277	sedoheptulokinase activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006098	pentose-phosphate shunt	TAS	biological process
GO:0005737	cytoplasm	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq