• Gene id: 23658

Gene Summary

• Gene Symbol: LSM5   Gene   UCSC   Ensembl
• Aliases: YER146W
• Gene name: LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
• Alternate names: U6 snRNA-associated Sm-like protein LSm5, LSM5 U6 small nuclear RNA and mRNA degradation associated, LSM5 homolog, U6 small nuclear RNA associated,
• Gene location: 7p14.3 (32495282: 32485332)     Exons: 6     NC_000014.9
• Gene summary(Entrez): Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length
• OMIM: 607285

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation
hsa03040	Spliceosome

Diseases

Associated diseases	References
Asthenozoospermia	MIK: 27232852
Male factor infertility	MIK: 27232852
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Asthenozoospermia, Male infertility	MIK: 27232852
Azoospermia, Oligozoospermia	MIK: 19478329
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27232852	Asthenozoospermia, Male infertility	rs215702 in LSM5	Chinese Han	592 (456 healthy fertile men, 136 subfertile men)	Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
19478329	Azoospermia, Oligozoospermia	rs215702	Caucasi an	50 cases	Male infertility	GWAS