• Gene id: 23654

Gene Summary

• Gene Symbol: PLXNB2   Gene   UCSC   Ensembl
• Aliases: MM1, Nbla00445, PLEXB2, dJ402G11.3
• Gene name: plexin B2
• Alternate names: plexin-B2,
• Gene location: 22q13.33 (50307645: 50274978)     Exons: 44     NC_000022.11
• Gene summary(Entrez): Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
• OMIM: 607588

Protein Summary

• Protein general information: O15031  
  • Name: Plexin B2 (MM1)
  • Length: 1838  
  • Mass: 205127
• Sequence:

  MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDN
  KKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEG
  VATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDG
  PYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRD
  SRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGS
  RDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDL
  GSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQ
  PQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRR
  GNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPL
  VIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNID
  SKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILG
  SNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSV
  EPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGI
  FFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHND
  TKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTL
  QEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSL
  ILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVL
  DYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYF
  ASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLF
  KAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYR
  GQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKVGVSQQPEDSQQDLP
  GERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAV
  PPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTR
  TEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQK
  YYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL

• Structural information:
  • Protein Domains: (20..46-)
    (/note="Sema-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00352-)
    (803..89-)
    (/note="IPT/TIG-1)
    (895..98-)
    (/note="IPT/TIG-2)
    (983..109-)
    (/note="IPT/TIG-3")
  • Interpro: IPR013783  IPR014756  IPR002909  IPR031148  IPR013548   IPR002165  IPR016201  IPR008936  IPR001627  IPR036352  IPR041019  IPR015943  
  • Prosite: PS51004
  • PDB: 4000 0000 0000 0000 1675 2610 2256 8458 3183 5965 7354 6656 1353 1325 7371 0847 2279 8592
  • PDBsum: 4000 0000 0000 0000 1675 2610 2256 8458 3183 5965 7354 6656 1353 1325 7371 0847 2279 8592
  • STRING: ENSP00000409171
• Other Databases: GeneCards:  PLXNB2  Malacards:  PLXNB2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	IDA	biological process
GO:0010976	positive regulation of neuron projection development	IDA	biological process
GO:0045727	positive regulation of translation	IMP	biological process
GO:0050772	positive regulation of axonogenesis	IBA	biological process
GO:0030334	regulation of cell migration	IBA	biological process
GO:0008360	regulation of cell shape	IBA	biological process
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	IBA	biological process
GO:0043087	regulation of GTPase activity	IBA	biological process
GO:0017154	semaphorin receptor activity	IBA	molecular function
GO:0007162	negative regulation of cell adhesion	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0002116	semaphorin receptor complex	IBA	cellular component
GO:0008360	regulation of cell shape	ISS	biological process
GO:0007405	neuroblast proliferation	ISS	biological process
GO:2001222	regulation of neuron migration	ISS	biological process
GO:0071526	semaphorin-plexin signaling pathway	ISS	biological process
GO:0043087	regulation of GTPase activity	ISS	biological process
GO:0017154	semaphorin receptor activity	ISS	molecular function
GO:0007420	brain development	ISS	biological process
GO:0005887	integral component of plasma membrane	ISS	cellular component
GO:0001932	regulation of protein phosphorylation	ISS	biological process
GO:0001843	neural tube closure	ISS	biological process
GO:1904861	excitatory synapse assembly	ISS	biological process
GO:0007165	signal transduction	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:0007275	multicellular organism development	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007405	neuroblast proliferation	IEA	biological process
GO:0008360	regulation of cell shape	IEA	biological process
GO:0050772	positive regulation of axonogenesis	IEA	biological process
GO:0001843	neural tube closure	IEA	biological process
GO:0001932	regulation of protein phosphorylation	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0007420	brain development	IEA	biological process
GO:0017154	semaphorin receptor activity	IEA	molecular function
GO:0043087	regulation of GTPase activity	IEA	biological process
GO:0071526	semaphorin-plexin signaling pathway	IEA	biological process
GO:1904861	excitatory synapse assembly	IEA	biological process
GO:2001222	regulation of neuron migration	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0009986	cell surface	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04360	Axon guidance

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq