• Gene id: 23649

Gene Summary

• Gene Symbol: POLA2   Gene   UCSC   Ensembl
• Gene name: DNA polymerase alpha 2, accessory subunit
• Alternate names: DNA polymerase alpha subunit B, DNA polymerase alpha 70 kDa subunit, polymerase (DNA directed), alpha 2 (70kD subunit), polymerase (DNA directed), alpha 2, accessory subunit, polymerase (DNA) alpha 2, accessory subunit, polymerase (DNA-directed), alpha (70kD),
• Gene location: 11q13.1 (65261916: 65306268)     Exons: 21     NC_000011.10
• OMIM: 182131

Protein Summary

• Protein general information: Q14181  
  • Name: DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit)
  • Length: 598  
  • Mass: 65948
• Sequence:

  MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLS
  KARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSS
  FSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIE
  ELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQ
  VVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVC
  ILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDK
  KQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESF
  YVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI

• Structural information:
  • Interpro: IPR007185  IPR043034  IPR016722  IPR013627  
  • PDB: 2KEB 4E2I 4Y97 5EXR
  • PDBsum: 2KEB 4E2I 4Y97 5EXR
  • STRING: ENSP00000265465
• Other Databases: GeneCards:  POLA2  Malacards:  POLA2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005658	alpha DNA polymerase:primase complex	IBA	cellular component
GO:0006270	DNA replication initiation	IBA	biological process
GO:0006260	DNA replication	IEA	biological process
GO:0003677	DNA binding	IEA	molecular function
GO:0006260	DNA replication	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005658	alpha DNA polymerase:primase complex	IDA	cellular component
GO:0006270	DNA replication initiation	TAS	biological process
GO:0000082	G1/S transition of mitotic cell cycle	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0032201	telomere maintenance via semi-conservative replication	TAS	biological process
GO:0032201	telomere maintenance via semi-conservative replication	TAS	biological process
GO:0032201	telomere maintenance via semi-conservative replication	TAS	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0006260	DNA replication	NAS	biological process
GO:0003674	molecular_function	ND	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03030	DNA replication

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881