• Gene id: 23643

Gene Summary

• Gene Symbol: LY96   Gene   UCSC   Ensembl
• Aliases: ESOP-1, MD-2, MD2, ly-96
• Gene name: lymphocyte antigen 96
• Alternate names: lymphocyte antigen 96, myeloid differentiation protein-2, protein MD-2,
• Gene location: 8q21.11 (73991274: 74099806)     Exons: 7     NC_000008.11
• Gene summary(Entrez): This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that thi
• OMIM: 605243

Protein Summary

• Protein general information: Q9Y6Y9  
  • Name: Lymphocyte antigen 96 (Ly 96) (ESOP 1) (Protein MD 2)
  • Length: 160  
  • Mass: 18546
• Sequence:

  MLPFLFFSTLFSSIFTEAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKRSKGLLHIFYIPRRDLKQLY
  FNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTTISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLE
  FVILHQPNSN

• Structural information:
  • Interpro: IPR014756  IPR039217  IPR003172  
  • PDB: 1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A
  • PDBsum: 1T2Z 2E56 2E59 2Z65 3FXI 3ULA 4G8A
  • DIP: 38571
  • STRING: ENSP00000284818
• Other Databases: GeneCards:  LY96  Malacards:  LY96

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071222	cellular response to lipopolysaccharide	IBA	biological process
GO:0032497	detection of lipopolysaccharide	IBA	biological process
GO:0046696	lipopolysaccharide receptor complex	IBA	cellular component
GO:0034142	toll-like receptor 4 signaling pathway	IBA	biological process
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IBA	biological process
GO:0001875	lipopolysaccharide immune receptor activity	IBA	molecular function
GO:0031226	intrinsic component of plasma membrane	IDA	cellular component
GO:0046696	lipopolysaccharide receptor complex	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0034142	toll-like receptor 4 signaling pathway	ISS	biological process
GO:0032760	positive regulation of tumor necrosis factor production	ISS	biological process
GO:0045087	innate immune response	IEA	biological process
GO:0001530	lipopolysaccharide binding	IEA	molecular function
GO:0035662	Toll-like receptor 4 binding	IEA	molecular function
GO:0045087	innate immune response	IEA	biological process
GO:0002376	immune system process	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0006954	inflammatory response	IEA	biological process
GO:0015026	coreceptor activity	TAS	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0006968	cellular defense response	TAS	biological process
GO:0007166	cell surface receptor signaling pathway	TAS	biological process
GO:0032496	response to lipopolysaccharide	IDA	biological process
GO:0002224	toll-like receptor signaling pathway	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0007249	I-kappaB kinase/NF-kappaB signaling	TAS	biological process
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0010008	endosome membrane	TAS	cellular component
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	biological process
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	TAS	biological process
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	TAS	biological process
GO:0002756	MyD88-independent toll-like receptor signaling pathway	TAS	biological process
GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway	TAS	biological process
GO:0070266	necroptotic process	TAS	biological process
GO:0097190	apoptotic signaling pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0071222	cellular response to lipopolysaccharide	IEA	biological process
GO:0031663	lipopolysaccharide-mediated signaling pathway	IEA	biological process
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway	IEA	biological process
GO:0032760	positive regulation of tumor necrosis factor production	IEA	biological process
GO:0034142	toll-like receptor 4 signaling pathway	IEA	biological process
GO:0046696	lipopolysaccharide receptor complex	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0032497	detection of lipopolysaccharide	IDA	biological process
GO:0046696	lipopolysaccharide receptor complex	IDA	cellular component
GO:0001875	lipopolysaccharide immune receptor activity	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05132	Salmonella infection
hsa04064	NF-kappa B signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa05145	Toxoplasmosis
hsa05133	Pertussis

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881