• Gene id: 23549

Gene Summary

• Gene Symbol: DNPEP   Gene   UCSC   Ensembl
• Aliases: ASPEP, DAP
• Gene name: aspartyl aminopeptidase
• Alternate names: aspartyl aminopeptidase,
• Gene location: 2q35 (219400006: 219372042)     Exons: 19     NC_000002.12
• Gene summary(Entrez): The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in general metabolism of intracellular proteins. Several tra
• OMIM: 611367

Protein Summary

• Protein general information: Q9ULA0  
  • Name: Aspartyl aminopeptidase (EC 3.4.11.21)
  • Length: 475  
  • Mass: 52428
  • Tissue specificity: Ubiquitous. {ECO
• Sequence:

  MQVAMNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSELKETEKWNIKPESKYFMTRNSSTIIA
  FAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQVGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRL
  EQQLVHVERPILRIPHLAIHLQRNINENFGPNTEMHLVPILATAIQEELEKGTPEPGPLNAVDERHHSVLMSLLC
  AHLGLSPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHVRMVTLYDN
  EEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEAIPKSFMISADMAHAVHPNYLDKHEENHRPLFHKGPVIKV
  NSKQRYASNAVSEALIREVANKVKVPLQDLMVRNDTPCGTTIGPILASRLGLRVLDLGSPQLAMHSIREMACTTG
  VLQTLTLFKGFFELFPSLSHNLLVD

• Structural information:
  • Interpro: IPR001948  IPR023358  
  • PDB: 4DYO
  • PDBsum: 4DYO
  • STRING: ENSP00000273075
• Other Databases: GeneCards:  DNPEP  Malacards:  DNPEP

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0070006	metalloaminopeptidase activity	IBA	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008270	zinc ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0004177	aminopeptidase activity	TAS	molecular function
GO:0005737	cytoplasm	TAS	cellular component
GO:0006518	peptide metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0072562	blood microparticle	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)