• Gene id: 23521

Gene Summary

• Gene Symbol: RPL13A   Gene   UCSC   Ensembl
• Aliases: L13A, TSTA1
• Gene name: ribosomal protein L13a
• Alternate names: 60S ribosomal protein L13a, 23 kDa highly basic protein, epididymis secretory sperm binding protein, large ribosomal subunit protein uL13, tissue specific transplantation antigen 1,
• Gene location: 19q13.33 (57186115: 57152465)     Exons: 15     NC_000016.10
• Gene summary(Entrez): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the

Protein Summary

• Protein general information: P40429  
  • Name: 60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)
  • Length: 203  
  • Mass: 23577
• Sequence:

  MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRA
  PSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQ
  AVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV

• Structural information:
  • Interpro: IPR005822  IPR023563  IPR005755  IPR036899  
  • Prosite: PS00783
  • CDD: cd00392
  • PDB: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • PDBsum: 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
  • STRING: ENSP00000375730
• Other Databases: GeneCards:  RPL13A  Malacards:  RPL13A

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0022625	cytosolic large ribosomal subunit	IBA	cellular component
GO:0017148	negative regulation of translation	IBA	biological process
GO:0005840	ribosome	IBA	cellular component
GO:0003729	mRNA binding	IBA	molecular function
GO:0003735	structural constituent of ribosome	IBA	molecular function
GO:1901194	negative regulation of formation of translation preinitiation complex	IDA	biological process
GO:0071346	cellular response to interferon-gamma	IDA	biological process
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0017148	negative regulation of translation	IDA	biological process
GO:0017148	negative regulation of translation	IDA	biological process
GO:0097452	GAIT complex	IDA	cellular component
GO:0097452	GAIT complex	IDA	cellular component
GO:0017148	negative regulation of translation	IMP	biological process
GO:0005840	ribosome	IEA	cellular component
GO:0006412	translation	IEA	biological process
GO:0003735	structural constituent of ribosome	IEA	molecular function
GO:0015934	large ribosomal subunit	IEA	cellular component
GO:0006417	regulation of translation	IEA	biological process
GO:0005840	ribosome	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003735	structural constituent of ribosome	TAS	molecular function
GO:0015934	large ribosomal subunit	TAS	cellular component
GO:1990904	ribonucleoprotein complex	IDA	cellular component
GO:0006413	translational initiation	TAS	biological process
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	TAS	biological process
GO:0019083	viral transcription	TAS	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005925	focal adhesion	HDA	cellular component
GO:0016020	membrane	HDA	cellular component
GO:0005634	nucleus	HDA	cellular component
GO:0005730	nucleolus	HDA	cellular component
GO:0022625	cytosolic large ribosomal subunit	HDA	cellular component
GO:0006412	translation	NAS	biological process
GO:0005737	cytoplasm	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0003735	structural constituent of ribosome	NAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03010	Ribosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray