• Gene id: 23507

Gene Summary

• Gene Symbol: LRRC8B   Gene   UCSC   Ensembl
• Aliases: TA-LRRP, TALRRP
• Gene name: leucine rich repeat containing 8 VRAC subunit B
• Alternate names: volume-regulated anion channel subunit LRRC8B, T-cell activation leucine repeat-rich protein, epididymis secretory sperm binding protein, leucine rich repeat containing 8 family member B, leucine-rich repeat-containing protein 8B,
• Gene location: 1p22.2 (89522625: 89597860)     Exons: 12     NC_000001.11
• OMIM: 617722

Protein Summary

• Protein general information: Q6P9F7  
  • Name: Volume regulated anion channel subunit LRRC8B (Leucine rich repeat containing protein 8B) (T cell activation leucine repeat rich protein) (TA LRRP)
  • Length: 803  
  • Mass: 92390
• Sequence:

  MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNHCAVPWDILKA
  SMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLE
  HFVAILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIESPTSSV
  LDKKEGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYK
  RYQCVYSLAEIFKVLASFYVILVILYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQ
  YDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELI
  PEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQ
  LSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERI
  PHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLPLQL
  FLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNL
  THLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPVTERLQTCLDKC

• Structural information:
  • Interpro: IPR001611  IPR003591  IPR026906  IPR032675  IPR021040  
  • Prosite: PS51450
  • DIP: 61361
  • STRING: ENSP00000332674
• Other Databases: GeneCards:  LRRC8B  Malacards:  LRRC8B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0071470	cellular response to osmotic stress	IBA	biological process
GO:0034702	ion channel complex	IBA	cellular component
GO:0015734	taurine transport	IBA	biological process
GO:0015810	aspartate transmembrane transport	IBA	biological process
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0004722	protein serine/threonine phosphatase activity	IBA	molecular function
GO:0005886	plasma membrane	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0034702	ion channel complex	IMP	cellular component
GO:0005225	volume-sensitive anion channel activity	IMP	contributes to
GO:0005515	protein binding	IPI	molecular function
GO:0098656	anion transmembrane transport	IMP	biological process
GO:0098656	anion transmembrane transport	IMP	biological process
GO:0005887	integral component of plasma membrane	IMP	cellular component
GO:0005783	endoplasmic reticulum	IEA	cellular component
GO:0006811	ion transport	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0055085	transmembrane transport	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005789	endoplasmic reticulum membrane	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0015698	inorganic anion transport	IEA	biological process
GO:0006470	protein dephosphorylation	IEA	biological process

Diseases

Associated diseases	References
Agammaglobulinemias	KEGG:H00085
Agammaglobulinemias	KEGG:H00085
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881