• Gene id: 23500

Gene Summary

• Gene Symbol: DAAM2   Gene   UCSC   Ensembl
• Aliases: dJ90A20A.1
• Gene name: dishevelled associated activator of morphogenesis 2
• Alternate names: disheveled-associated activator of morphogenesis 2,
• Gene location: 6p21.2 (39792365: 39904876)     Exons: 31     NC_000006.12
• OMIM: 600179

Protein Summary

• Protein general information: Q86T65  
  • Name: Disheveled associated activator of morphogenesis 2
  • Length: 1068  
  • Mass: 123499
  • Tissue specificity: Expressed in most tissues examined. {ECO
• Sequence:

  MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELDLTDKNREAMFALPPE
  KKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDEEETEMRNQVVEDLKTALRTQPMRFVTRFIE
  LEGLTCLLNFLRSMDHATCESRIHTSLIGCIKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGA
  VCLVPGGHKKVLQAMLHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL
  RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMFELIHKKLKYTEAYPC
  LLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEVKQWRDQAEK
  FRKEHMELVSRLERKERECETKTLEKEEMMRTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPP
  GGPLTLSSSMTTNDLPPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ
  PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDIYLASRKVKELSVIDG
  RRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEHKHEIERMARADRFLYEMS
  RIDHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASL
  NKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRR
  QVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGIFDTFLQAFSEARQDL
  EAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEGGEFDDLVSALRSGEVFDKDLCKLKRSRKRS
  GSQALEVTRERAINRLNY

• Structural information:
  • Protein Domains: (40..41-)
    (/note="GBD/FH3-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00579-)
    (518..59-)
    (/note="FH1-)
    (595..99-)
    (/note="FH2-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00774-)
    (1016..104-)
    (/note="DAD-)
    (/evidence="ECO:0000255|-)
  • Interpro: IPR011989  IPR016024  IPR014767  IPR015425  IPR042201   IPR010472  IPR014768  IPR010473  
  • Prosite: PS51231 PS51444 PS51232
  • STRING: ENSP00000381876
• Other Databases: GeneCards:  DAAM2  Malacards:  DAAM2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0090263	positive regulation of canonical Wnt signaling pathway	IBA	biological process
GO:2000050	regulation of non-canonical Wnt signaling pathway	IBA	biological process
GO:0048715	negative regulation of oligodendrocyte differentiation	IBA	biological process
GO:0048715	negative regulation of oligodendrocyte differentiation	ISS	biological process
GO:0021516	dorsal spinal cord development	ISS	biological process
GO:2000050	regulation of non-canonical Wnt signaling pathway	ISS	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	ISS	biological process
GO:0060828	regulation of canonical Wnt signaling pathway	ISS	biological process
GO:0003779	actin binding	IEA	molecular function
GO:0017048	Rho GTPase binding	IEA	molecular function
GO:0030036	actin cytoskeleton organization	IEA	biological process
GO:0016043	cellular component organization	IEA	biological process
GO:0016055	Wnt signaling pathway	IEA	biological process
GO:0048715	negative regulation of oligodendrocyte differentiation	IEA	biological process
GO:0021516	dorsal spinal cord development	IEA	biological process
GO:2000050	regulation of non-canonical Wnt signaling pathway	IEA	biological process
GO:0090263	positive regulation of canonical Wnt signaling pathway	IEA	biological process
GO:0060828	regulation of canonical Wnt signaling pathway	IEA	biological process
GO:0007368	determination of left/right symmetry	IEA	biological process
GO:0070062	extracellular exosome	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04310	Wnt signaling pathway

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Hypospadias	MIK: 25108383

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
25108383	Hypospadias	rs417096		1,006 boys who underwent surgery for hypospadias and 5,486 individuals (2,390 males and 3,096 females)	Male infertility	GWAS