• Gene id: 23476

Gene Summary

• Gene Symbol: BRD4   Gene   UCSC   Ensembl
• Aliases: CAP, HUNK1, HUNKI, MCAP
• Gene name: bromodomain containing 4
• Alternate names: bromodomain-containing protein 4, chromosome-associated protein,
• Gene location: 19p13.12 (15332542: 15236835)     Exons: 23     NC_000019.10
• Gene summary(Entrez): The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence
• OMIM: 608749

Protein Summary

• Protein general information: O60885  
  • Name: Bromodomain containing protein 4 (Protein HUNK1)
  • Length: 1362  
  • Mass: 152,219
• Sequence:

  MSAESGPGTRLRNLPVMGDGLETSQMSTTQAQAQPQPANAASTNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLW
  KHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMA
  EALEKLFLQKINELPTEETEIMIVQAKGRGRGRKETGTAKPGVSTVPNTTQASTPPQTQTPQPNPPPVQATPHPF
  PAVTPDLIVQTPVMTVVPPQPLQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTI
  DPIHEPPSLPPEPKTTKLGQRRESSRPVKPPKKDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWP
  FYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVF
  EMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAVHEQL
  AALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYE
  SEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCL
  RKKRKPQAEKVDVIAGSSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAP
  APVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQ
  PILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSNRAAALPPKPARPPAVSPALTQTPLL
  PQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPSVQQQLQQQPP
  PPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHK
  SDPYSTGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPF
  SPSLRPEPPKHPESIKAPVHLPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMG
  SWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKEEREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRA
  HEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQRELARKREQERRRREAMAATIDMNFQ
  SDLLSIFEENLF

• Structural information:
  • Protein Domains: Bromo (75-147)
    Bromo (368-440)
    NET. (600-682)
  • Interpro: IPR031354  IPR001487  IPR036427  IPR018359  IPR027353   IPR038336  
  • Prosite: PS00633 PS50014 PS51525
  • PDB: 2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR
  • PDBsum: 2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR
  • DIP: 39776
  • STRING: ENSP00000263377
• Other Databases: GeneCards:  BRD4  Malacards:  BRD4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	IMP	biological process
GO:0000794	condensed nuclear chromosome	IDA	cellular component
GO:0002039	p53 binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005694	chromosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006338	chromatin remodeling	IDA	biological process
GO:0006351	transcription, DNA-templated	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP	biological process
GO:0016032	viral process	IEA	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IMP	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0050727	regulation of inflammatory response	IDA	biological process
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	IDA	biological process
GO:2000002	negative regulation of DNA damage checkpoint	IMP	biological process
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	IMP	biological process
GO:0000794	condensed nuclear chromosome	IDA	cellular component
GO:0002039	p53 binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005694	chromosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006338	chromatin remodeling	IDA	biological process
GO:0006351	transcription, DNA-templated	IEA	biological process
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IEA	biological process
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP	biological process
GO:0016032	viral process	IEA	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IMP	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0050727	regulation of inflammatory response	IDA	biological process
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	IDA	biological process
GO:2000002	negative regulation of DNA damage checkpoint	IMP	biological process
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	IMP	biological process
GO:0000794	condensed nuclear chromosome	IDA	cellular component
GO:0002039	p53 binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0003682	chromatin binding	IDA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005694	chromosome	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006338	chromatin remodeling	IDA	biological process
GO:0006974	cellular response to DNA damage stimulus	IMP	biological process
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	IMP	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IMP	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	IDA	biological process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA	biological process
GO:0050727	regulation of inflammatory response	IDA	biological process
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:0070577	lysine-acetylated histone binding	IDA	molecular function
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	IDA	biological process
GO:2000002	negative regulation of DNA damage checkpoint	IMP	biological process

Diseases

Associated diseases	References
Non obstructive azoospermia	MIK: 25374327
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Non- obstructive azoospermia	MIK: 25374327
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
25374327	Non- obstructive azoospermia	RNF8 (rs195432, rs195434, rs2284922)	Chinese Han	729 (361 men with NOA, 368 fertile controls)	Male infertility	RNF8 BRDT
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq