• Gene id: 23475

Gene Summary

• Gene Symbol: QPRT   Gene   UCSC   Ensembl
• Aliases: HEL-S-90n, QPRTase
• Gene name: quinolinate phosphoribosyltransferase
• Alternate names: nicotinate-nucleotide pyrophosphorylase [carboxylating], epididymis secretory sperm binding protein Li 90n, nicotinate-nucleotide pyrophosphorylase (carboxylating),
• Gene location: 16p11.2 (29670587: 29698698)     Exons: 5     NC_000016.10
• Gene summary(Entrez): This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has
• OMIM: 604907

Protein Summary

• Protein general information: Q15274  
  • Name: Nicotinate nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) (QPRTase)
  • Length: 297  
  • Mass: 30846
• Sequence:

  MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFL
  PEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKY
  GLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFK
  PEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

• Structural information:
  • Interpro: IPR013785  IPR004393  IPR027277  IPR036068  IPR037128   IPR002638  IPR022412  
  • CDD: cd01572
  • PDB: 2JBM 4KWV 4KWW 5AYX 5AYY 5AYZ
  • PDBsum: 2JBM 4KWV 4KWW 5AYX 5AYY 5AYZ
  • STRING: ENSP00000378782
• Other Databases: GeneCards:  QPRT  Malacards:  QPRT

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IBA	molecular function
GO:0005737	cytoplasm	IBA	cellular component
GO:0009435	NAD biosynthetic process	IBA	biological process
GO:0034213	quinolinate catabolic process	IBA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	molecular function
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0016763	transferase activity, transferring pentosyl groups	IEA	molecular function
GO:0016740	transferase activity	IEA	molecular function
GO:0019363	pyridine nucleotide biosynthetic process	IEA	biological process
GO:0016757	transferase activity, transferring glycosyl groups	IEA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	molecular function
GO:0034213	quinolinate catabolic process	IDA	biological process
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	TAS	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0019674	NAD metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0046874	quinolinate metabolic process	IEA	biological process
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IEA	molecular function
GO:0009435	NAD biosynthetic process	IEA	biological process
GO:0034213	quinolinate catabolic process	IDA	biological process
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA	molecular function
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA	molecular function
GO:0034213	quinolinate catabolic process	IDA	biological process
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity	IDA	molecular function
GO:0034213	quinolinate catabolic process	IDA	biological process
GO:1902494	catalytic complex	IDA	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa00760	Nicotinate and nicotinamide metabolism

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq