• Gene id: 23435

Gene Summary

• Gene Symbol: TARDBP   Gene   UCSC   Ensembl
• Aliases: ALS10, TDP-43
• Gene name: TAR DNA binding protein
• Alternate names: TAR DNA-binding protein 43, TAR DNA-binding protein-43,
• Gene location: 1p36.22 (11012621: 11030527)     Exons: 8     NC_000001.11
• Gene summary(Entrez): HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA
• OMIM: 605078

Diseases

Associated diseases	References
Frontotemporal lobar degeneration	GAD: 20645878
Parkinson disease	GAD: 19204172
Amyotrophic lateral sclerosis (ALS)	KEGG: H00058
Alzheimer's disease	GAD: 19851068
Dementia	GAD: 17614162
Male factor infertility	MIK: 25359468
Spermatogenesis defects	MIK: 21252238
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Male factor infertility	MIK: 25359468
Regulates spatiotemporal expression of the acrv1 gene during spermatogenesis	MIK: 21252238
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21252238	Regulates spatiotemporal expression of the acrv1 gene during spermatogenesis				Male infertility
25359468	Male factor infertility			109 (11 fertile, 98 subfertile men)	Male infertility
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881