• Gene id: 23424

Gene Summary

• Gene Symbol: TDRD7   Gene   UCSC   Ensembl
• Aliases: CATC4, PCTAIRE2BP, TRAP
• Gene name: tudor domain containing 7
• Alternate names: tudor domain-containing protein 7, PCTAIRE2-binding protein, epididymis secretory sperm binding protein, tudor repeat associator with PCTAIRE 2,
• Gene location: 9q22.33 (97412095: 97496124)     Exons: 17     NC_000009.12
• Gene summary(Entrez): The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated wit
• OMIM: 611258

Protein Summary

• Protein general information: Q8NHU6  
  • Name: Tudor domain containing protein 7 (PCTAIRE2 binding protein) (Tudor repeat associator with PCTAIRE 2) (Trap)
  • Length: 1098  
  • Mass: 123586
• Sequence:

  MLEGDLVSKMLRAVLQSHKNGVALPRLQGEYRSLTGDWIPFKQLGFPTLEAYLRSVPAVVRIETSRSGEITCYAM
  ACTETARIAQLVARQRSSKRKTGRQVNCQMRVKKTMPFFLEGKPKATLRQPGFASNFSVGKKPNPAPLRDKGNSV
  GVKPDAEMSPYMLHTTLGNEAFKDIPVQRHVTMSTNNRFSPKASLQPPLQMHLSRTSTKEMSDNLNQTVEKPNVK
  PPASYTYKMDEVQNRIKEILNKHNNGIWISKLPHFYKELYKEDLNQGILQQFEHWPHICTVEKPCSGGQDLLLYP
  AKRKQLLRSELDTEKVPLSPLPGPKQTPPLKGCPTVMAGDFKEKVADLLVKYTSGLWASALPKAFEEMYKVKFPE
  DALKNLASLSDVCSIDYISGNPQKAILYAKLPLPTDKIQKDAGQAHGDNDIKAMVEQEYLQVEESIAESANTFME
  DITVPPLMIPTEASPSVLVVELSNTNEVVIRYVGKDYSAAQELMEDEMKEYYSKNPKITPVQAVNVGQLLAVNAE
  EDAWLRAQVISTEENKIKVCYVDYGFSENVEKSKAYKLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTC
  GKIFAVEILDKADIPLVVLYDTSGEDDININATCLKAICDKSLEVHLQVDAMYTNVKVTNICSDGTLYCQVPCKG
  LNKLSDLLRKIEDYFHCKHMTSECFVSLPFCGKICLFHCKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSEL
  REIPPRFLQEMIAIPPQAIKCCLADLPQSIGMWTPDAVLWLRDSVLNCSDCSIKVTKVDETRGIAHVYLFTPKNF
  PDPHRSINRQITNADLWKHQKDVFLSAISSGADSPNSKNGNMPMSGNTGENFRKNLTDVIKKSMVDHTSAFSTEE
  LPPPVHLSKPGEHMDVYVPVACHPGYFVIQPWQEIHKLEVLMEEMILYYSVSEERHIAVEKDQVYAAKVENKWHR
  VLLKGILTNGLVSVYELDYGKHELVNIRKVQPLVDMFRKLPFQAVTAQLAGVKCNQWSEEASMVFRNHVEKKPLV
  ALVQTVIENANPWDRKVVVYLVDTSLPDTDTWIHDFMSEYLIELSKVN

• Structural information:
  • Protein Domains: (3..7-)
    1 (/note="HTH-OST-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00975-)
    (233..30-)
    2 (/note="HTH-OST-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00975-)
    (337..40-)
    3 (/note="HTH-OST-type)
    (/evidence="ECO:0000255|PROSIT-)
  • Interpro: IPR041966  IPR025605  IPR035437  IPR037978  IPR002999  
  • Prosite: PS51644 PS50304
  • CDD: cd09974
  • PDB: 3RCO
  • PDBsum: 3RCO
  • STRING: ENSP00000347444
• Other Databases: GeneCards:  TDRD7  Malacards:  TDRD7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003729	mRNA binding	IDA	molecular function
GO:0035770	ribonucleoprotein granule	IDA	cellular component
GO:0070306	lens fiber cell differentiation	IMP	biological process
GO:0007283	spermatogenesis	ISS	biological process
GO:0033391	chromatoid body	ISS	cellular component
GO:0010608	posttranscriptional regulation of gene expression	IMP	biological process
GO:0005737	cytoplasm	ISS	cellular component
GO:0002089	lens morphogenesis in camera-type eye	IMP	biological process
GO:0007283	spermatogenesis	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005759	mitochondrial matrix	IEA	cellular component
GO:0047485	protein N-terminus binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component

Diseases

Associated diseases	References
Cataract	KEGG:H01202
Cataract	KEGG:H01202
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Nonobstructive azoospermia	MIK: 28837160
Nonobstructive azoospermia	MIK: 31048812
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
31048812	Nonobstructive azoospermia	c.324_325insA (T110Nfs*30), c.688_689insA (p.Y230X)		698 (178 patients with azoospermia, 520 controls)	Male infertility	NGS
28837160	Nonobstructive azoospermia	c.324_325insA (T110Nfs*30) and c.688_689insA (p.Y230X)		698 (176 patients with azoospermia, 520 healthy controls)	Male infertility	NGS
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray