• Gene id: 23423

Gene Summary

• Gene Symbol: TMED3   Gene   UCSC   Ensembl
• Aliases: C15orf22, P24B, p24g4, p24gamma4, p26
• Gene name: transmembrane p24 trafficking protein 3
• Alternate names: transmembrane emp24 domain-containing protein 3, integral type I protein, membrane protein p24B, p24 family protein gamma-4, testis tissue sperm-binding protein Li 48e, transmembrane emp24 protein transport domain containing 3,
• Gene location: 15q25.1 (79311061: 79413885)     Exons: 6     NC_000015.10

Protein Summary

• Protein general information: Q9Y3Q3  
  • Name: Transmembrane emp24 domain containing protein 3 (Membrane protein p24B) (p24 family protein gamma 4) (p24gamma4) (p26)
  • Length: 217  
  • Mass: 24777
• Sequence:

  MGSTVPRSASVLLLLLLLRRAEQPCGAELTFELPDNAKQCFHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPQGN
  TIYRETKKQYDSFTYRAEVKGVYQFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEA
  LKTVIDSQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLKSFFTEKRPISRAVHS

• Structural information:
  • Protein Domains: (38..12-)
    (/note="GOLD-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00096"-)
  • Interpro: IPR009038  IPR036598  IPR015720  
  • Prosite: PS50866
  • STRING: ENSP00000299705
• Other Databases: GeneCards:  TMED3  Malacards:  TMED3

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881