|
Gene id |
23410 |
| Gene Summary KEGG pathways Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
SIRT3 Gene UCSC Ensembl |
|
Aliases |
SIR2L3 |
|
Gene name |
sirtuin 3 |
|
Alternate names |
NAD-dependent protein deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-3, mitochondrial, SIR2-like protein 3, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, regulatory protein SIR2 homolog 3, silent mating type i, |
|
Gene location |
11p15.5 (236930: 215029) Exons: 10 NC_000011.10
|
|
Gene summary(Entrez) |
SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent th
|
|
OMIM |
604481 |
|
| Pathway id | Pathway name |
|---|
| hsa01100 | Metabolic pathways | | hsa05230 | Central carbon metabolism in cancer | |
|
| Associated diseases |
References |
| Poor developmental outcomes for human oocytes after in vitro maturation | INFBASE: 26787646 |
| Reduced ovarian reserve | INFBASE: 24771001 |
| Low Sperm motility | MIK: 21674046 |
| Associated with spermatogenesis and epigenetic regulation | MIK: 21674046 |
| Cryptorchidism | MIK: 28606200 |
| Low sperm motility | MIK: 21674046 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 21674046 |
Low sperm
motility
|
|
|
|
Male infertility |
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|