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Gene id 23387
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary

Gene Symbol SIK3   Gene   UCSC   Ensembl
Aliases L19, QSK, SEMDK, SIK-3
Gene name SIK family kinase 3
Alternate names serine/threonine-protein kinase SIK3, salt-inducible kinase 3, serine/threonine-protein kinase QSK,
Gene location 11q23.3 (117098452: 116843409)     Exons: 31     NC_000011.10
OMIM 614776

Protein Summary

Protein general information Q9Y2K2  

Name: Serine/threonine protein kinase SIK3 (EC 2.7.11.1) (Salt inducible kinase 3) (SIK 3) (Serine/threonine protein kinase QSK)

Length: 1321  Mass: 144851

Tissue specificity: Expressed in chondrocytes. {ECO

Sequence MAAAAASGAGGAAGAGTGGAGPAGRLLPPPAPGSPAAPAAVSPAAGQPRPPAPASRGPMPARIGYYEIDRTIGKG
NFAVVKRATHLVTKAKVAIKIIDKTQLDEENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEI
FDHLVAHGRMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSNLFTPGQLLKTWCGS
PPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNLRARVLSGKFRIPFFMSTECEHLIRHMLVL
DPNKRLSMEQICKHKWMKLGDADPNFDRLIAECQQLKEERQVDPLNEDVLLAMEDMGLDKEQTLQSLRSDAYDHY
SAIYSLLCDRHKRHKTLRLGALPSMPRALAFQAPVNIQAEQAGTAMNISVPQVQLINPENQIVEPDGTLNLDSDE
GEEPSPEALVRYLSMRRHTVGVADPRTEVMEDLQKLLPGFPGVNPQAPFLQVAPNVNFMHNLLPMQNLQPTGQLE
YKEQSLLQPPTLQLLNGMGPLGRRASDGGANIQLHAQQLLKRPRGPSPLVTMTPAVPAVTPVDEESSDGEPDQEA
VQSSTYKDSNTLHLPTERFSPVRRFSDGAASIQAFKAHLEKMGNNSSIKQLQQECEQLQKMYGGQIDERTLEKTQ
QQHMLYQQEQHHQILQQQIQDSICPPQPSPPLQAACENQPALLTHQLQRLRIQPSSPPPNHPNNHLFRQPSNSPP
PMSSAMIQPHGAASSSQFQGLPSRSAIFQQQPENCSSPPNVALTCLGMQQPAQSQQVTIQVQEPVDMLSNMPGTA
AGSSGRGISISPSAGQMQMQHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPHLFSDQSR
GSPSSYSPSTGVGFSPTQALKVPPLDQFPTFPPSAHQQPPHYTTSALQQALLSPTPPDYTRHQQVPHILQGLLSP
RHSLTGHSDIRLPPTEFAQLIKRQQQQRQQQQQQQQQQEYQELFRHMNQGDAGSLAPSLGGQSMTERQALSYQNA
DSYHHHTSPQHLLQIRAQECVSQASSPTPPHGYAHQPALMHSESMEEDCSCEGAKDGFQDSKSSSTLTKGCHDSP
LLLSTGGPGDPESLLGTVSHAQELGIHPYGHQPTAAFSKNKVPSREPVIGNCMDRSSPGQAVELPDHNGLGYPAR
PSVHEHHRPRALQRHHTIQNSDDAYVQLDNLPGMSLVAGKALSSARMSDAVLSQSSLMGSQQFQDGENEECGASL
GGHEHPDLSDGSQHLNSSCYPSTCITDILLSYKHPEVSFSMEQAGV
Structural information
Protein Domains
(66..31-)
(/note="Protein-kinase)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00159-)
(344..38-)
(/note="UBA-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00212"-)
Interpro:  IPR011009  IPR000719  IPR017441  IPR008271  IPR034672  
IPR015940  
Prosite:   PS00107 PS50011 PS00108 PS50030
CDD:   cd14071
MINT:  
STRING:   ENSP00000364449
Other Databases GeneCards:  SIK3  Malacards:  SIK3

Gene ontology

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GO accessionTerm nameEvidence codeGo category
GO:0000226 microtubule cytoskeleton
organization
IBA biological process
GO:0004674 protein serine/threonine
kinase activity
IBA molecular function
GO:0005737 cytoplasm
IBA cellular component
GO:0035556 intracellular signal tran
sduction
IBA biological process
GO:0050321 tau-protein kinase activi
ty
IBA molecular function
GO:0004674 protein serine/threonine
kinase activity
IDA molecular function
GO:1904515 positive regulation of TO
RC2 signaling
IMP biological process
GO:1904263 positive regulation of TO
RC1 signaling
IMP biological process
GO:0005515 protein binding
IPI molecular function
GO:0004672 protein kinase activity
IEA molecular function
GO:0004674 protein serine/threonine
kinase activity
IEA molecular function
GO:0005524 ATP binding
IEA molecular function
GO:0006468 protein phosphorylation
IEA biological process
GO:0046872 metal ion binding
IEA molecular function
GO:0016301 kinase activity
IEA molecular function
GO:0016740 transferase activity
IEA molecular function
GO:0016310 phosphorylation
IEA biological process
GO:0005524 ATP binding
IEA molecular function
GO:0005737 cytoplasm
IEA cellular component
GO:0004674 protein serine/threonine
kinase activity
IEA molecular function
GO:0000166 nucleotide binding
IEA molecular function
GO:0005515 protein binding
IPI molecular function
GO:0005737 cytoplasm
IEA cellular component
GO:0005524 ATP binding
IDA molecular function
GO:0000287 magnesium ion binding
IDA molecular function
GO:0006468 protein phosphorylation
IDA biological process
GO:0004674 protein serine/threonine
kinase activity
IDA molecular function
Associated diseases References
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
17327269 Teratozoos
permia

19 (6 controls
, 13 cases)
Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm

18
Male infertility GSE26881
Show abstract
28606200 Cryptorchi
dism

Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
Male infertility MeDIP-Seq
Show abstract