• Gene id: 23373

Gene Summary

• Gene Symbol: CRTC1   Gene   UCSC   Ensembl
• Aliases: MAML2, MECT1, Mam-2, TORC-1, TORC1, WAMTP1
• Gene name: CREB regulated transcription coactivator 1
• Alternate names: CREB-regulated transcription coactivator 1, Mastermind-like protein 2, mucoepidermoid carcinoma translocated protein 1, transducer of regulated cAMP response element-binding protein (CREB) 1,
• Gene location: 19p13.11 (18683620: 18782332)     Exons: 18     NC_000019.10
• OMIM: 606102

Protein Summary

• Protein general information: Q6UUV9  
  • Name: CREB regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element binding protein 1) (TORC 1) (Transducer of CREB protein 1)
  • Length: 634  
  • Mass: 67300
  • Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. {
• Sequence:

  MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGT
  MDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTN
  SDSALHQSTMTPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEVPGINIFP
  SADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSSSTGNLAANLTHLGIGGAGQGMSTP
  GSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPP
  ASQQPPPPPPPQAPVRLPPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTS
  AGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQFNMMENAISSSSLYSPGS
  TLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVTGESPPSLSKELTSSLAGVGDVSFDSDSQFPLDEL
  KIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL

• Structural information:
  • Interpro: IPR024786  IPR024785  IPR024784  IPR024783  
  • STRING: ENSP00000345001
• Other Databases: GeneCards:  CRTC1  Malacards:  CRTC1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0032793	positive regulation of CREB transcription factor activity	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0008140	cAMP response element binding protein binding	IBA	molecular function
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0043153	entrainment of circadian clock by photoperiod	ISS	biological process
GO:0032793	positive regulation of CREB transcription factor activity	ISS	biological process
GO:0032793	positive regulation of CREB transcription factor activity	IEA	biological process
GO:0051289	protein homotetramerization	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0008140	cAMP response element binding protein binding	IEA	molecular function
GO:0048511	rhythmic process	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0016032	viral process	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:1902631	negative regulation of membrane hyperpolarization	IEA	biological process
GO:0043153	entrainment of circadian clock by photoperiod	IEA	biological process
GO:0032793	positive regulation of CREB transcription factor activity	IEA	biological process
GO:0007613	memory	IEA	biological process
GO:1900006	positive regulation of dendrite development	IEA	biological process
GO:0099527	postsynapse to nucleus signaling pathway	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0030425	dendrite	IEA	cellular component
GO:0097009	energy homeostasis	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:1900273	positive regulation of long-term synaptic potentiation	IEA	biological process
GO:0045202	synapse	IEA	cellular component
GO:0043025	neuronal cell body	IEA	cellular component
GO:0014069	postsynaptic density	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0016604	nuclear body	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	biological process
GO:0008140	cAMP response element binding protein binding	IDA	molecular function
GO:0005634	nucleus	IDA	cellular component
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa05166	Human T-cell leukemia virus 1 infection

Diseases

Associated diseases	References
Salivary gland cancer	KEGG:H01508
Salivary gland cancer	KEGG:H01508
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq