|
Gene id |
23353 |
| Gene Summary Diseases PubMed |
Gene Summary
|
|
Gene Symbol |
SUN1 Gene UCSC Ensembl |
|
Aliases |
UNC84A |
|
Gene name |
Sad1 and UNC84 domain containing 1 |
|
Alternate names |
SUN domain-containing protein 1, Sad1 unc-84 domain protein 1, protein unc-84 homolog A, sad1/unc-84 protein-like 1, unc-84 homolog A, |
|
Gene location |
7p22.3 (815556: 874933) Exons: 30 NC_000007.14
|
|
Gene summary(Entrez) |
This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by R
|
|
OMIM |
607723 |
|
| Associated diseases |
References |
| Connect the differentiating spermatid nucleus to surrounding cytoskeletal structures to enable its well-directed shaping and elongation, which in turn is a critical parameter for male fertility | MIK: 20711465 |
| Connect the differentiating spermatid nucleus to surrounding cytoskeletal structures to enable its well-directed shaping and elongation, which in turn is a critical parameter for male fertility | MIK: 20711465 |
| Cryptorchidism | MIK: 28606200 |
| Spermatogenic defects | MIK: 31037746 |
| Teratozoospermia | MIK: 17327269 |
|
|
| PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
| 20711465 |
Connect th
e differen
tiating sp
ermatid nu
cleus to s
urrounding
cytoskele
tal struct
ures to en
able its w
ell-direct
ed shaping
and elong
ation, whi
ch in turn
is a crit
ical param
eter for m
ale fertil
ity
|
|
|
|
Male infertility |
|
Show abstract |
| 17327269 |
Teratozoos
permia
|
|
|
19 (6 controls
, 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
| 28606200 |
Cryptorchi
dism
|
|
|
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
28 men with az
oospermia
|
Male infertility |
Microarray
|
Show abstract |
| 31037746 |
Spermatoge
nic defect
s
|
|
|
16 (1 control,
15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|