• Gene id: 23284

Gene Summary

• Gene Symbol: ADGRL3   Gene   UCSC   Ensembl
• Aliases: CIRL3, CL3, LEC3, LPHN3
• Gene name: adhesion G protein-coupled receptor L3
• Alternate names: adhesion G protein-coupled receptor L3, CIRL-3, calcium-independent alpha-latrotoxin receptor 3, latrophilin homolog 3 (cow), latrophilin-3, lectomedin 3,
• Gene location: 4q13.1 (61201229: 62078334)     Exons: 32     NC_000004.12
• Gene summary(Entrez): This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cystein
• OMIM: 608148

Protein Summary

• Protein general information: Q9HAR2  
  • Name: Adhesion G protein coupled receptor L3 (Calcium independent alpha latrotoxin receptor 3) (CIRL 3) (Latrophilin 3) (Lectomedin 3)
  • Length: 1447  
  • Mass: 161812
• Sequence:

  MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMEN
  IRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFE
  SDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERT
  RNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGT
  WDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNL
  LYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPSVKDISTTGPLGMGSTTTSTTLRTTTLS
  PGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGT
  IGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVG
  LLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTVEESAFVLADNLLKTD
  IVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMK
  LGTEALSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCR
  LLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIH
  KNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGY
  GMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNI
  KSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKS
  TESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLN
  GNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNLMNKLVNNLGSGR
  EDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQPHHYTRRRIPQDHSESFFPLLTNEHTEDLQS
  PHRDSLYTSMPTLAGVAATESVTTSTQTEPPPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVP
  PNKDGTPPEGSSKGPAHLVTSL

• Structural information:
  • Protein Domains: (35..12-)
    (/note="SUEL-type-lectin)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00260-)
    (134..39-)
    (/note="Olfactomedin-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00446-)
    (802..85-)
    (/note="GPS-)
    (/evidence="ECO:0000255|PROSITE-Pr-)
  • Interpro: IPR032471  IPR017981  IPR036445  IPR001879  IPR003924   IPR003334  IPR000832  IPR017983  IPR000203  IPR015630  IPR000922  IPR003112  
  • Prosite: PS00650 PS50227 PS50261 PS50221 PS51132 PS50228
  • PDB: 5CMN
  • PDBsum: 5CMN
  • DIP: 56228
  • STRING: ENSP00000422533
• Other Databases: GeneCards:  ADGRL3  Malacards:  ADGRL3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004930	G protein-coupled receptor activity	IBA	molecular function
GO:0005887	integral component of plasma membrane	IBA	cellular component
GO:0007416	synapse assembly	IBA	biological process
GO:0007420	brain development	IBA	biological process
GO:0005911	cell-cell junction	IBA	cellular component
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	biological process
GO:0030424	axon	IBA	cellular component
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IBA	biological process
GO:0098978	glutamatergic synapse	IBA	cellular component
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IDA	biological process
GO:0005509	calcium ion binding	IDA	molecular function
GO:0005887	integral component of plasma membrane	IDA	cellular component
GO:0030424	axon	ISS	cellular component
GO:0005911	cell-cell junction	ISS	cellular component
GO:0001764	neuron migration	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0007416	synapse assembly	ISS	biological process
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007166	cell surface receptor signaling pathway	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0030054	cell junction	IEA	cellular component
GO:0042995	cell projection	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016021	integral component of membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0004930	G protein-coupled receptor activity	TAS	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0016021	integral component of membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0051965	positive regulation of synapse assembly	IEA	biological process
GO:0042220	response to cocaine	IEA	biological process
GO:0007416	synapse assembly	IEA	biological process
GO:0005887	integral component of plasma membrane	IEA	cellular component
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	IEA	biological process
GO:0050808	synapse organization	IEA	biological process
GO:0031987	locomotion involved in locomotory behavior	IEA	biological process
GO:0030424	axon	IEA	cellular component
GO:0005911	cell-cell junction	IEA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0001764	neuron migration	IEA	biological process
GO:0030054	cell junction	IEA	cellular component
GO:0030424	axon	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	NAS	molecular function
GO:0016021	integral component of membrane	NAS	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	NAS	biological process

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq