• Gene id: 23255

Gene Summary

• Gene Symbol: MTCL1   Gene   UCSC   Ensembl
• Aliases: CCDC165, KIAA0802, SOGA2
• Gene name: microtubule crosslinking factor 1
• Alternate names: microtubule cross-linking factor 1, PAR-1-interacting protein, SOGA family member 2, coiled-coil domain containing 165, coiled-coil domain-containing protein 165,
• Gene location: 18p11.22 (8705555: 8832777)     Exons: 27     NC_000018.10
• OMIM: 608042

Protein Summary

• Protein general information: Q9Y4B5  
  • Name: Microtubule cross linking factor 1 (Coiled coil domain containing protein 165) (PAR 1 interacting protein) (SOGA family member 2)
  • Length: 1905  
  • Mass: 209526
• Sequence:

  METLNGPAGGGAPDAKLQPPGQHHRHHHLHPVAERRRLHRAPSPARPFLKDLHARPAAPGPAVPSSGRAPAPAAP
  RSPNLAGKAPPSPGSLAAPGRLSRRSGGVPGAKDKPPPGAGARAAGGAKAALGSRRAARVAPAEPLSRAGKPPGA
  EPPSAAAKGRKAKRGSRAPPARTVGPPTPAARIPAVTLAVTSVAGSPARCSRISHTDSSSDLSDCPSEPLSDEQR
  LLPAASSDAESGTGSSDREPPRGAPTPSPAARGAPPGSPEPPALLAAPLAAGACPGGRSIPSGVSGGFAGPGVAE
  DVRGRSPPERPVPGTPKEPSLGEQSRLVPAAEEEELLREMEELRSENDYLKDELDELRAEMEEMRDSYLEEDVYQ
  LQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAE
  DENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQDDSADLRCQLQFAKEEAFLMRKKMAK
  LGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEME
  DMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPR
  EPGWLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESD
  AGKKESDGEESRLPQPKREGPVGGESDSEEMFEKTSGFGSGKPSEASEPCPTELLKAREDSEYLVTLKHEAQRLE
  RTVERLITDTDSFLHDAGLRGGAPLPGPGLQGEEEQGEGDQQEPQLLGTINAKMKAFKKELQAFLEQVNRIGDGL
  SPLPHLTESSSFLSTVTSVSRDSPIGNLGKELGPDLQSRLKEQLEWQLGPARGDERESLRLRAARELHRRADGDT
  GSHGLGGQTCFSLEMEEEHLYALRWKELEMHSLALQNTLHERTWSDEKNLMQQELRSLKQNIFLFYVKLRWLLKH
  WRQGKQMEEEGEEFTEGEHPETLSRLGELGVQGGHQADGPDHDSDRGCGFPVGEHSPHSRVQIGDHSLRLQTADR
  GQPHKQVVENQQLFSAFKALLEDFRAELREDERARLRLQQQYASDKAAWDVEWAVLKCRLEQLEEKTENKLGELG
  SSAESKGALKKEREVHQKLLADSHSLVMDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQK
  ENSPRRGGSFLCDQKDGNVRPFPHQGSLRMPRPVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLD
  DEPEEPPAHRPEREFRNRLPEEEENHKGNLQRAVSVSSMSEFQRLMDISPFLPEKGLPSTSSKEDVTPPLSPDDL
  KYIEEFNKSWDYTPNRGHNGGGPDLWADRTEVGRAGHEDSTEPFPDSSWYLTTSVTMTTDTMTSPEHCQKQPLRS
  HVLTEQSGLRVLHSPPAVRRVDSITAAGGEGPFPTSRARGSPGDTKGGPPEPMLSRWPCTSPRHSRDYVEGARRP
  LDSPLCTSLGFASPLHSLEMSKNLSDDMKEVAFSVRNAICSGPGELQVKDMACQTNGSRTMGTQTVQTISVGLQT
  EALRGSGVTSSPHKCLTPKAGGGATPVSSPSRSLRSRQVAPAIEKVQAKFERTCCSPKYGSPKLQRKPLPKADQP
  NNRTSPGMAQKGYSESAWARSTTTRESPVHTTINDGLSSLFNIIDHSPVVQDPFQKGLRAGSRSRSAEPRPELGP
  GQETGTNSRGRSPSPIGVGSEMCREEGGEGTPVKQDLSAPPGYTLTENVARILNKKLLEHALKEERRQAAHGPPG
  LHSDSHSLGDTAEPGPMENQTVLLTAPWGL

• Structural information:
  • Interpro: IPR027882  IPR027881  
  • STRING: ENSP00000352927
• Other Databases: GeneCards:  MTCL1  Malacards:  MTCL1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0008017	microtubule binding	IBA	molecular function
GO:0016328	lateral plasma membrane	IBA	cellular component
GO:0000922	spindle pole	IBA	cellular component
GO:0001578	microtubule bundle formation	IBA	biological process
GO:0016327	apicolateral plasma membrane	IBA	cellular component
GO:0030496	midbody	IBA	cellular component
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	IBA	biological process
GO:0097427	microtubule bundle	IBA	cellular component
GO:0008017	microtubule binding	IDA	molecular function
GO:0030496	midbody	IDA	cellular component
GO:0005856	cytoskeleton	IDA	cellular component
GO:0000922	spindle pole	IDA	cellular component
GO:2000576	positive regulation of microtubule motor activity	ISS	biological process
GO:0042803	protein homodimerization activity	ISS	molecular function
GO:0016328	lateral plasma membrane	ISS	cellular component
GO:0016328	lateral plasma membrane	ISS	cellular component
GO:0097427	microtubule bundle	ISS	cellular component
GO:0097427	microtubule bundle	ISS	cellular component
GO:0090314	positive regulation of protein targeting to membrane	ISS	biological process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	ISS	biological process
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	ISS	biological process
GO:0016327	apicolateral plasma membrane	ISS	cellular component
GO:0016327	apicolateral plasma membrane	ISS	cellular component
GO:0001578	microtubule bundle formation	ISS	biological process
GO:0001578	microtubule bundle formation	ISS	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0010506	regulation of autophagy	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0042803	protein homodimerization activity	IEA	molecular function
GO:0016328	lateral plasma membrane	IEA	cellular component
GO:0000922	spindle pole	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0016324	apical plasma membrane	IEA	cellular component
GO:0030496	midbody	IEA	cellular component
GO:0003723	RNA binding	HDA	molecular function

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray