• Gene id: 23248

Gene Summary

• Gene Symbol: RPRD2   Gene   UCSC   Ensembl
• Aliases: HSPC099, KIAA0460
• Gene name: regulation of nuclear pre-mRNA domain containing 2
• Alternate names: regulation of nuclear pre-mRNA domain-containing protein 2,
• Gene location: 1q21.2 (150364110: 150476565)     Exons: 11     NC_000001.11
• OMIM: 614695

Protein Summary

• Protein general information: Q5VT52  
  • Name: Regulation of nuclear pre mRNA domain containing protein 2
  • Length: 1461  
  • Mass: 156020
• Sequence:

  MAAGGGGGSSKASSSSASSAGALESSLDRKFQSVTNTMESIQGLSSWCIENKKHHSTIVYHWMKWLRRSAYPHRL
  NLFYLANDVIQNCKRKNAIIFRESFADVLPEAAALVKDPSVSKSVERIFKIWEDRNVYPEEMIVALREALSTTFK
  TQKQLKENLNKQPNKQWKKSQTSTNPKAALKSKIVAEFRSQALIEELLLYKRSEDQIELKEKQLSTMRVDVCSTE
  TLKCLKDKTGGKKFSKEFEEASSKLEEFVNGLDKQVKNGPSLTEALENAGIFYEAQYKEVKVVANAYKTFANRVN
  NLKKKLDQLKSTLPDPEESPVPSPSMDAPSPTGSESPFQGMGGEESQSPTMESEKSATPEPVTDNRDVEDMELSD
  VEDDGSKIIVEDRKEKPAEKSAVSTSVPTKPTENISKASSCTPVPVTMTATPPLPKPVNTSLSPSPALALPNLAN
  VDLAKISSILSSLTSVMKNTGVSPASRPSPGTPTSPSNLTSGLKTPAPATTTSHNPLANILSKVEITPESILSAL
  SKTQTQSAPALQGLSSLLQSVTGNPVPASEAASQSTSASPANTTVSTIKGRNLPSSAQPFIPKSFNYSPNSSTSE
  VSSTSASKASIGQSPGLPSTTFKLPSNSLGFTATHNTSPAAPPTEVTICQSSEVSKPKLESESTSPSLEMKIHNF
  LKGNPGFSGLNLNIPILSSLGSSAPSESHPSDFQRGPTSTSIDNIDGTPVRDERSGTPTQDEMMDKPTSSSVDTM
  SLLSKIISPGSSTPSSTRSPPPGRDESYPRELSNSVSTYRPFGLGSESPYKQPSDGMERPSSLMDSSQEKFYPDT
  SFQEDEDYRDFEYSGPPPSAMMNLEKKPAKSILKSSKLSDTTEYQPILSSYSHRAQEFGVKSAFPPSVRALLDSS
  ENCDRLSSSPGLFGAFSVRGNEPGSDRSPSPSKNDSFFTPDSNHNSLSQSTTGHLSLPQKQYPDSPHPVPHRSLF
  SPQNTLAAPTGHPPTSGVEKVLASTISTTSTIEFKNMLKNASRKPSDDKHFGQAPSKGTPSDGVSLSNLTQPSLT
  ATDQQQQEEHYRIETRVSSSCLDLPDSTEEKGAPIETLGYHSASNRRMSGEPIQTVESIRVPGKGNRGHGREASR
  VGWFDLSTSGSSFDNGPSSASELASLGGGGSGGLTGFKTAPYKERAPQFQESVGSFRSNSFNSTFEHHLPPSPLE
  HGTPFQREPVGPSSAPPVPPKDHGGIFSRDAPTHLPSVDLSNPFTKEAALAHAAPPPPPGEHSGIPFPTPPPPPP
  PGEHSSSGGSGVPFSTPPPPPPPVDHSGVVPFPAPPLAEHGVAGAVAVFPKDHSSLLQGTLAEHFGVLPGPRDHG
  GPTQRDLNGPGLSRVRESLTLPSHSLEHLGPPHGGGGGGGSNSSSGPPLGPSHRDTISRSGIILRSPRPDFRPRE
  PFLSRDPFHSLKRPRPPFARGPPFFAPKRPFFPPRY

• Structural information:
  • Protein Domains: (19..14-)
    (/note="CID-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00724"-)
  • Interpro: IPR006569  IPR032337  IPR008942  IPR006903  
  • Prosite: PS51391
  • PDB: 4FLB
  • PDBsum: 4FLB
  • DIP: 31155
  • STRING: ENSP00000358064
• Other Databases: GeneCards:  RPRD2  Malacards:  RPRD2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000993	RNA polymerase II complex binding	IBA	molecular function
GO:0016591	RNA polymerase II, holoenzyme	IBA	cellular component
GO:0031124	mRNA 3'-end processing	IBA	biological process
GO:0016591	RNA polymerase II, holoenzyme	IDA	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0042795	snRNA transcription by RNA polymerase II	TAS	biological process

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)