• Gene id: 23173

Gene Summary

• Gene Symbol: METAP1   Gene   UCSC   Ensembl
• Aliases: MAP1A, MetAP1A
• Gene name: methionyl aminopeptidase 1
• Alternate names: methionine aminopeptidase 1, MAP 1, metAP 1, peptidase M 1,
• Gene location: 4q23 (98995692: 99063108)     Exons: 19     NC_000004.12
• OMIM: 603939

Protein Summary

• Protein general information: P53582  
  • Name: Methionine aminopeptidase 1 (MAP 1) (MetAP 1) (EC 3.4.11.18) (Peptidase M 1)
  • Length: 386  
  • Mass: 43215
• Sequence:

  MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINT
  DPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVL
  DVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYR
  NGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
  HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRL
  DSARPHFMSQF

• Structural information:
  • Interpro: IPR036005  IPR000994  IPR001714  IPR002467  IPR031615  
  • Prosite: PS00680
  • CDD: cd01086
  • PDB: 2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7
  • PDBsum: 2B3H 2B3K 2B3L 2G6P 2GZ5 2NQ6 2NQ7 4FLI 4FLJ 4FLK 4FLL 4HXX 4IKR 4IKS 4IKT 4IKU 4IU6 4U1B 4U69 4U6C 4U6E 4U6J 4U6W 4U6Z 4U70 4U71 4U73 4U75 4U76 5YKP 5YR4 5YR5 5YR6 5YR7
  • STRING: ENSP00000296411
• Other Databases: GeneCards:  METAP1  Malacards:  METAP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006417	regulation of translation	TAS	biological process
GO:0031365	N-terminal protein amino acid modification	TAS	biological process
GO:0018206	peptidyl-methionine modification	TAS	biological process
GO:0005737	cytoplasm	TAS	cellular component
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008235	metalloexopeptidase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008233	peptidase activity	IEA	molecular function
GO:0004177	aminopeptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0022400	regulation of rhodopsin mediated signaling pathway	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0070084	protein initiator methionine removal	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0070006	metalloaminopeptidase activity	IEA	molecular function
GO:0070527	platelet aggregation	HMP	biological process
GO:0004177	aminopeptidase activity	TAS	molecular function
GO:0008235	metalloexopeptidase activity	TAS	molecular function

Diseases

Associated diseases	References
Hypospermatogenesis	MIK: 28361989

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28361989	Hypospermatogenesis			6 (3 controls, 3 Klienfelter syndrome	Male infertility	Microarray