• Gene id: 23161

Gene Summary

• Gene Symbol: SNX13   Gene   UCSC   Ensembl
• Aliases: RGS-PX1
• Gene name: sorting nexin 13
• Alternate names: sorting nexin-13, rgs domain- and phox domain-containing protein,
• Gene location: 7p21.1 (17940507: 17790760)     Exons: 33     NC_000007.14
• Gene summary(Entrez): This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are i
• OMIM: 606589

Protein Summary

• Protein general information: Q9Y5W8  
  • Name: Sorting nexin 13 (RGS domain and PHOX domain containing protein) (RGS PX1)
  • Length: 968  
  • Mass: 112189
• Sequence:

  MLTEASLSIWGWGSLGIVLFLITFGPFVIFYLTFYILCFVGGGLVVTLLFGKTNSEKYLEQCEHSFLPPTSPGVP
  KCLEEMKREARTIKIDRRLTGANIIDEPLQQVIQFSLRDYVQYWYYTLSDDESFLLEIRQTLQNALIQFATRSKE
  IDWQPYFTTRIVDDFGTHLRVFRKAQQKITEKDDQVKGTAEDLVDTFFEVEVEMEKEVCRDLVCTSPKDEEGFLR
  DLCEVLLYLLLPPGDFQNKIMRYFVREILARGILLPLINQLSDPDYINQYVIWMIRDSNCNYEAFMNIIKLSDNI
  GELEAVRDKAAEELQYLRSLDTAGDDINTIKNQINSLLFVKKVCDSRIQRLQSGKEINTVKLAANFGKLCTVPLD
  SILVDNVALQFFMDYMQQTGGQAHLFFWMTVEGYRVTAQQQLEVLLSRQRDGKHQTNQTKGLLRAAAVGIYEQYL
  SEKASPRVTVDDYLVAKLADTLNHEDPTPEIFDDIQRKVYELMLRDERFYPSFRQNALYVRMLAELDMLKDPSFR
  GSDDGDGESFNGSPTGSINLSLDDLSNVSSDDSVQLHAYISDTVYADYDPYAVAGVCNDHGKTYALYAITVHRRN
  LNSEEMWKTYRRYSDFHDFHMRITEQFESLSSILKLPGKKTFNNMDRDFLEKRKKDLNAYLQLLLAPEMMKASPA
  LAHYVYDFLENKAYSKGKGDFARKMDTFVNPLRNSMRNVSNAVKSLPDSLAEGMTKMSDNMGKMSERLGQDIKQS
  FFKVPPLIPKTDSDPEHRRVSAQLDDNVDDNIPLRVMLLLMDEVFDLKERNQWLRRNIKNLLQQLIRATYGDTIN
  RKIVDHVDWMTSPEQVADSVKRFRDAFWPNGILAEAVPCRDKSIRMRTRVAGKTKLLAIMPDELKHIIGAETTRK
  GILRVFEMFQHNQLNRRMVYVFLEGFLETLFPQYKFRELFNKLHSRSKQMQKYKQKLQTTQAPSLQKR

• Structural information:
  • Protein Domains: (97..28-)
    (/note="PXA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00147,-ECO:0000255|PROSITE-ProRule:PRU00553)
    (373..49-)
    (/note="RGS-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00171-)
    (570..69-)
    (/note="PX-)
    (/evidence="ECO:0000255|-)
  • Interpro: IPR001683  IPR003114  IPR036871  IPR016137  IPR036305   IPR037437  IPR037896  IPR013937  
  • Prosite: PS50195 PS51207 PS50132
  • CDD: cd06873 cd08719
  • STRING: ENSP00000398789
• Other Databases: GeneCards:  SNX13  Malacards:  SNX13

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0043547	positive regulation of GTPase activity	IDA	biological process
GO:0035091	phosphatidylinositol binding	IDA	molecular function
GO:0005769	early endosome	IDA	cellular component
GO:0006886	intracellular protein transport	IMP	biological process
GO:0035091	phosphatidylinositol binding	IEA	molecular function
GO:0043547	positive regulation of GTPase activity	IEA	biological process
GO:0009968	negative regulation of signal transduction	IEA	biological process
GO:0005768	endosome	IEA	cellular component
GO:0008289	lipid binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0015031	protein transport	IEA	biological process
GO:0031901	early endosome membrane	IEA	cellular component
GO:0032266	phosphatidylinositol-3-phosphate binding	IDA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)