• Gene id: 23105

Gene Summary

• Gene Symbol: FSTL4   Gene   UCSC   Ensembl
• Gene name: follistatin like 4
• Alternate names: follistatin-related protein 4, follistatin-like protein 4,
• Gene location: 5q31.1 (133842065: 133194826)     Exons: 19     NC_000005.10

Protein Summary

• Protein general information: Q6MZW2  
  • Name: Follistatin related protein 4 (Follistatin like protein 4)
  • Length: 842  
  • Mass: 93096
• Sequence:

  MKPGGFWLHLTLLGASLPAALGWMDPGTSRGPDVGVGESQAEEPRSFEVTRREGLSSHNELLASCGKKFCSRGSR
  CVLSRKTGEPECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKN
  VLLALQTRLQPLQEGDSRQDPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFD
  DYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNGLTLNFLDLEDINDF
  GEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWL
  KNGVDVSTQMSKQLSLLANGSELHISSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSV
  GNMFYVFSDDGIIVIHPVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVL
  VVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLIRTPFAGVDDFFIPP
  TNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHGCVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVD
  SVTDSVLGPNGDVTGTPHTSPDGRFIVSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYN
  IYAALHTEPDLLFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQNTLRC
  EVSGIKGGTTVVWVGEV

• Structural information:
  • Protein Domains: (81..13-)
    (/note="Kazal-like-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00798-)
    (174..20-)
    (/note="EF-hand-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00448-)
    (251..33-)
    (/note="Ig-like-1)
    (341..42-)
    (/note="Ig-like-2")
  • Interpro: IPR011992  IPR018247  IPR002048  IPR007110  IPR036179   IPR013783  IPR003599  IPR003598  IPR002350  IPR036058  IPR015943  
  • Prosite: PS00018 PS50222 PS50835 PS51465
  • STRING: ENSP00000265342
• Other Databases: GeneCards:  FSTL4  Malacards:  FSTL4

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0030154	cell differentiation	IBA	biological process
GO:0007275	multicellular organism development	IBA	biological process
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0061000	negative regulation of dendritic spine development	IEA	biological process
GO:0048671	negative regulation of collateral sprouting	IEA	biological process
GO:0048403	brain-derived neurotrophic factor binding	IEA	molecular function
GO:0030141	secretory granule	IEA	cellular component
GO:0048670	regulation of collateral sprouting	IEA	biological process
GO:0031549	negative regulation of brain-derived neurotrophic factor receptor signaling pathway	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq