• Gene id: 23075

Gene Summary

• Gene Symbol: SWAP70   Gene   UCSC   Ensembl
• Aliases: HSPC321, SWAP-70
• Gene name: switching B cell complex subunit SWAP70
• Alternate names: switch-associated protein 70, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70,
• Gene location: 11p15.4 (9664076: 9752992)     Exons: 13     NC_000011.10
• OMIM: 604762

Protein Summary

• Protein general information: Q9UH65  
  • Name: Switch associated protein 70 (SWAP 70)
  • Length: 585  
  • Mass: 68998
  • Tissue specificity: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed
• Sequence:

  MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNR
  FILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAM
  GGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRK
  NWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQA
  IHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKK
  RLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQ
  ARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLE
  MATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE

• Structural information:
  • Protein Domains: (210..30-)
    (/note="PH-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00145"-)
  • Interpro: IPR011992  IPR002048  IPR011993  IPR001849  
  • Prosite: PS50003
  • PDB: 2DN6
  • PDBsum: 2DN6
  • STRING: ENSP00000315630
• Other Databases: GeneCards:  SWAP70  Malacards:  SWAP70

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005634	nucleus	IBA	cellular component
GO:0005737	cytoplasm	IBA	cellular component
GO:0005509	calcium ion binding	IEA	molecular function
GO:0042995	cell projection	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0003677	DNA binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0033633	negative regulation of cell-cell adhesion mediated by integrin	IEA	biological process
GO:0032233	positive regulation of actin filament bundle assembly	IEA	biological process
GO:0016444	somatic cell DNA recombination	IEA	biological process
GO:0008064	regulation of actin polymerization or depolymerization	IEA	biological process
GO:1902309	negative regulation of peptidyl-serine dephosphorylation	IEA	biological process
GO:0060754	positive regulation of mast cell chemotaxis	IEA	biological process
GO:0051017	actin filament bundle assembly	IEA	biological process
GO:0045190	isotype switching	IEA	biological process
GO:0032880	regulation of protein localization	IEA	biological process
GO:0030835	negative regulation of actin filament depolymerization	IEA	biological process
GO:0007204	positive regulation of cytosolic calcium ion concentration	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005524	ATP binding	IEA	molecular function
GO:0003677	DNA binding	IEA	molecular function
GO:0045296	cadherin binding	HDA	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0030027	lamellipodium	IEA	cellular component
GO:0005856	cytoskeleton	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0015629	actin cytoskeleton	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881