• Gene id: 23070

Gene Summary

• Gene Symbol: CMTR1   Gene   UCSC   Ensembl
• Aliases: FTSJD2, KIAA0082, MTr1, hMTr1
• Gene name: cap methyltransferase 1
• Alternate names: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1, FtsJ methyltransferase domain containing 2, ISG95, S-adenosyl-L-methionine-dependent methyltransferase FTSJD2, cap1 2'O-ribose methyltransferase 1, ftsJ methyltransferase domain-containing protein 2, int,
• Gene location: 6p21.2 (37433213: 37482843)     Exons: 25     NC_000006.12
• OMIM: 611668

Protein Summary

• Protein general information: Q8N1G2  
  • Name: Cap specific mRNA (nucleoside 2' O ) methyltransferase 1 (EC 2.1.1.57) (Cap methyltransferase 1) (Cap1 2'O ribose methyltransferase 1) (MTr1) (hMTr1) (FtsJ methyltransferase domain containing protein 2) (Interferon stimulated gene 95 kDa protein) (ISG95)
  • Length: 835  
  • Mass: 95321
• Sequence:

  MKRRTDPECTAPIKKQKKRVAELALSLSSTSDDEPPSSVSHGAKASTTSLSGSDSETEGKQHSSDSFDDAFKADS
  LVEGTSSRYSMYNSVSQKLMAKMGFREGEGLGKYSQGRKDIVEASSQKGRRGLGLTLRGFDQELNVDWRDEPEPS
  ACEQVSWFPECTTEIPDTQEMSDWMVVGKRKMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTRANPYE
  MIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGKPLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGM
  TLKGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENISAFRNFVLDNTDRKGVHFLMADGGFSVEGQENL
  QEILSKQLLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFERVCLFKPITSRPANSERYVVCKGLK
  VGIDDVRDYLFAVNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSLQIKALAKIHAFVQDTTLSE
  PRQAEIRKECLRLWGIPDQARVAPSSSDPKSKFFELIQGTEIDIFSYKPTLLTSKTLEKIRPVFDYRCMVSGSEQ
  KFLIGLGKSQIYTWDGRQSDRWIKLDLKTELPRDTLLSVEIVHELKGEGKAQRKISAIHILDVLVLNGTDVREQH
  FNQRIQLAEKFVKAVSKPSRPDMNPIRVKEVYRLEEMEKIFVRLEMKIIKGSSGTPKLSYTGRDDRHFVPMGLYI
  VRTVNEPWTMGFSKSFKKKFFYNKKTKDSTFDLPADSIAPFHICYYGRLFWEWGDGIRVHDSQKPQDQDKLSKED
  VLSFIQMHRA

• Structural information:
  • Protein Domains: (87..13-)
    (/note="G-patch-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00092-)
    (231..45-)
    2'-O-MTase (/note="RrmJ-type-SAM-dependent)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00945-)
    (752..78-)
    (/note="WW-)
    (/evidence="ECO:0000255|PRO-)
  • Interpro: IPR030376  IPR000467  IPR025816  IPR002877  IPR029063   IPR001202  
  • Prosite: PS50174 PS51613 PS01159
  • PDB: 4N48 4N49 4N4A
  • PDBsum: 4N48 4N49 4N4A
  • STRING: ENSP00000362550
• Other Databases: GeneCards:  CMTR1  Malacards:  CMTR1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0006370	7-methylguanosine mRNA capping	IBA	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IBA	molecular function
GO:0097309	cap1 mRNA methylation	IBA	biological process
GO:0005737	cytoplasm	IBA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0006370	7-methylguanosine mRNA capping	IDA	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IDA	molecular function
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IDA	molecular function
GO:0097309	cap1 mRNA methylation	IDA	biological process
GO:0080009	mRNA methylation	IDA	biological process
GO:0005634	nucleus	IDA	cellular component
GO:0006370	7-methylguanosine mRNA capping	IMP	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IEA	molecular function
GO:0006370	7-methylguanosine mRNA capping	IEA	biological process
GO:0032259	methylation	IEA	biological process
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0080009	mRNA methylation	IEA	biological process
GO:0016740	transferase activity	IEA	molecular function
GO:0032259	methylation	IEA	biological process
GO:0006370	7-methylguanosine mRNA capping	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0008168	methyltransferase activity	IEA	molecular function
GO:0006397	mRNA processing	IEA	biological process
GO:0004483	mRNA (nucleoside-2'-O-)-methyltransferase activity	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881