• Gene id: 23066

Gene Summary

• Gene Symbol: CAND2   Gene   UCSC   Ensembl
• Aliases: TIP120B, Tp120b
• Gene name: cullin associated and neddylation dissociated 2 (putative)
• Alternate names: cullin-associated NEDD8-dissociated protein 2, TBP interacting protein, TBP-interacting protein 120B, TBP-interacting protein of 120 kDa B, cullin-associated and neddylation-dissociated protein 2, epididymis secretory sperm binding protein, epididymis tissue pr,
• Gene location: 3p25.2 (12796653: 12834817)     Exons: 17     NC_000003.12
• OMIM: 617007

Protein Summary

• Protein general information: O75155  
  • Name: Cullin associated NEDD8 dissociated protein 2 (Cullin associated and neddylation dissociated protein 2) (Epididymis tissue protein Li 169) (TBP interacting protein of 120 kDa B) (TBP interacting protein 120B) (p120 CAND2)
  • Length: 1236  
  • Mass: 135256
  • Tissue specificity: Expressed in epididymis (at protein level). {ECO
• Sequence:

  MSTAAFHISSLLEKMTSSDKDFRFMATSDLMSELQKDSIQLDEDSERKVVKMLLRLLEDKNGEVQNLAVKCLGPL
  VVKVKEYQVETIVDTLCTNMRSDKEQLRDIAGIGLKTVLSELPPAATGSGLATNVCRKITGQLTSAIAQQEDVAV
  QLEALDILSDMLSRLGVPLGAFHASLLHCLLPQLSSPRLAVRKRAVGALGHLAAACSTDLFVELADHLLDRLPGP
  RVPTSPTAIRTLIQCLGSVGRQAGHRLGAHLDRLVPLVEDFCNLDDDELRESCLQAFEAFLRKCPKEMGPHVPNV
  TSLCLQYIKHDPNYNYDSDEDEEQMETEDSEFSEQESEDEYSDDDDMSWKVRRAAAKCIAALISSRPDLLPDFHC
  TLAPVLIRRFKEREENVKADVFTAYIVLLRQTQPPKGWLEAMEEPTQTGSNLHMLRGQVPLVVKALQRQLKDRSV
  RARQGCFSLLTELAGVLPGSLAEHMPVLVSGIIFSLADRSSSSTIRMDALAFLQGLLGTEPAEAFHPHLPILLPP
  VMACVADSFYKIAAEALVVLQELVRALWPLHRPRMLDPEPYVGEMSAVTLARLRATDLDQEVKERAISCMGHLVG
  HLGDRLGDDLEPTLLLLLDRLRNEITRLPAIKALTLVAVSPLQLDLQPILAEALHILASFLRKNQRALRLATLAA
  LDALAQSQGLSLPPSAVQAVLAELPALVNESDMHVAQLAVDFLATVTQAQPASLVEVSGPVLSELLRLLRSPLLP
  AGVLAAAEGFLQALVGTRPPCVDYAKLISLLTAPVYEQAVDGGPGLHKQVFHSLARCVAALSAACPQEAASTASR
  LVCDARSPHSSTGVKVLAFLSLAEVGQVAGPGHQRELKAVLLEALGSPSEDVRAAASYALGRVGAGSLPDFLPFL
  LEQIEAEPRRQYLLLHSLREALGAAQPDSLKPYAEDIWALLFQRCEGAEEGTRGVVAECIGKLVLVNPSFLLPRL
  RKQLAAGRPHTRSTVITAVKFLISDQPHPIDPLLKSFIGEFMESLQDPDLNVRRATLAFFNSAVHNKPSLVRDLL
  DDILPLLYQETKIRRDLIREVEMGPFKHTVDDGLDVRKAAFECMYSLLESCLGQLDICEFLNHVEDGLKDHYDIR
  MLTFIMVARLATLCPAPVLQRVDRLIEPLRATCTAKVKAGSVKQEFEKQDELKRSAMRAVAALLTIPEVGKSPIM
  ADFSSQIRSNPELAALFESIQKDSASAPSTDSMELS

• Structural information:
  • Interpro: IPR011989  IPR016024  IPR039852  IPR013932  
  • STRING: ENSP00000387641
• Other Databases: GeneCards:  CAND2  Malacards:  CAND2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005829	cytosol	IDA	cellular component
GO:0005634	nucleus	IBA	cellular component
GO:0010265	SCF complex assembly	IBA	biological process
GO:0016567	protein ubiquitination	IBA	biological process
GO:0010265	SCF complex assembly	IEA	biological process
GO:0005634	nucleus	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0017025	TBP-class protein binding	IEA	molecular function
GO:0005634	nucleus	IEA	cellular component
GO:0045893	positive regulation of transcription, DNA-templated	ISS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq