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Gene id 23030
Gene Summary    Protein Summary    Gene ontology    Diseases    PubMed    

Gene Summary
Gene Symbol KDM4B   Gene   UCSC   Ensembl
Aliases JMJD2B, TDRD14B
Gene name lysine demethylase 4B
Alternate names lysine-specific demethylase 4B, jmjC domain-containing histone demethylation protein 3B, jumonji domain containing 2B, jumonji domain-containing protein 2B, lysine (K)-specific demethylase 4B, tudor domain containing 14B,
Gene location 19p13.3 (4969086: 5153602)     Exons: 31     NC_000019.10
OMIM 609765

Protein Summary
Protein general information O94953  

Name: Lysine specific demethylase 4B (EC 1.14.11. ) (JmjC domain containing histone demethylation protein 3B) (Jumonji domain containing protein 2B)

Length: 1096  Mass: 121897

Sequence MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQV
VTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWN
IGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAI
GFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDY
GKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRSHR
KRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKA
KSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPI
IPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTF
SKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNA
AAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIG
DDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVP
EARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVS
ITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLG
PPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAF
SGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF
Structural information
Protein Domains
 (15..5-)
(/note="JmjN-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00537-)
(146..30-)
(/note="JmjC-)
(/evidence="ECO:0000255|PROSITE-ProRule:PRU00538-)
(917..97-)
(/note="Tudor-1)
(975..103-)
(/note="Tudor-2")
Interpro:  IPR034732  IPR003347  IPR003349  IPR040477  IPR002999  
IPR011011  IPR001965  IPR013083  
Prosite:   PS51805 PS51184 PS51183

PDB:  		 4LXL 4UC4
PDBsum:   4LXL 4UC4

DIP:  
47283
MINT:  
STRING:   ENSP00000159111
Other Databases GeneCards:  KDM4B  Malacards:  KDM4B

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0035097 histone methyltransferase
complex
 IBA cellular component
GO:0032454 histone demethylase activ
ity (H3-K9 specific)
 IBA molecular function
GO:0032452 histone demethylase activ
ity
 IBA molecular function
GO:0006338 chromatin remodeling
 IBA biological process
GO:0005634 nucleus
 IBA cellular component
GO:0032454 histone demethylase activ
ity (H3-K9 specific)
 IMP molecular function
GO:0033169 histone H3-K9 demethylati
on
 IMP biological process
GO:0006325 chromatin organization
 IEA biological process
GO:0046872 metal ion binding
 IEA molecular function
GO:0055114 oxidation-reduction proce
ss
 IEA biological process
GO:0005634 nucleus
 IEA cellular component
GO:0016491 oxidoreductase activity
 IEA molecular function
GO:0051213 dioxygenase activity
 IEA molecular function
GO:0032454 histone demethylase activ
ity (H3-K9 specific)
 IEA molecular function
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0005654 nucleoplasm
 TAS cellular component
GO:0032454 histone demethylase activ
ity (H3-K9 specific)
 TAS molecular function
GO:0005634 nucleus
 IEA cellular component
GO:0032454 histone demethylase activ
ity (H3-K9 specific)
 IDA molecular function
GO:0070544 histone H3-K36 demethylat
ion
 IDA biological process
GO:0033169 histone H3-K9 demethylati
on
 IDA biological process
GO:0051864 histone demethylase activ
ity (H3-K36 specific)
 IDA molecular function

Diseases

Expand All | Collapse All
Associated diseases References
medulloblastoma PMID:19270706
Prostate cancer PMID:22120715
Stomach cancer PMID:22133676
Stomach cancer PMID:24077348
Stomach cancer PMID:22133676
urinary bladder cancer PMID:21930796
lung cancer PMID:21930796
Breast cancer PMID:21445275
Breast cancer PMID:21445275
Malignant peripheral nerve sheath tumor PMID:21785329
colorectal cancer PMID:24473398
Alopecia areata PMID:21936853
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract