• Gene id: 23016

Gene Summary

• Gene Symbol: EXOSC7   Gene   UCSC   Ensembl
• Aliases: EAP1, RRP42, Rrp42p, hRrp42p, p8
• Gene name: exosome component 7
• Alternate names: exosome complex component RRP42, exosome complex exonuclease RRP42, ribosomal RNA-processing protein 42,
• Gene location: 3p21.31 (11256181: 11254416)     Exons: 2     NC_000016.10
• OMIM: 606488

Protein Summary

• Protein general information: Q15024  
  • Name: Exosome complex component RRP42 (Exosome component 7) (Ribosomal RNA processing protein 42) (p8)
  • Length: 291  
  • Mass: 31821
• Sequence:

  MASVTLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPN
  EGYLEFFVDCSASATPEFEGRGGDDLGTEIANTLYRIFNNKSSVDLKTLCISPREHCWVLYVDVLLLECGGNLFD
  AISIAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLAS
  LLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHASLQSVVHKEESLGPKRQKVGFLG

• Structural information:
  • Interpro: IPR001247  IPR015847  IPR036345  IPR027408  IPR020568  
  • PDB: 2NN6 6D6Q 6D6R 6H25
  • PDBsum: 2NN6 6D6Q 6D6R 6H25
  • DIP: 31266
  • STRING: ENSP00000265564
• Other Databases: GeneCards:  EXOSC7  Malacards:  EXOSC7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000176	nuclear exosome (RNase complex)	IBA	cellular component
GO:0000177	cytoplasmic exosome (RNase complex)	IBA	cellular component
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA	biological process
GO:0034475	U4 snRNA 3'-end processing	IBA	biological process
GO:0034476	U5 snRNA 3'-end processing	IBA	biological process
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	IBA	biological process
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	IBA	biological process
GO:0016075	rRNA catabolic process	IBA	biological process
GO:0017091	AU-rich element binding	IBA	molecular function
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	IBA	biological process
GO:0034473	U1 snRNA 3'-end processing	IBA	biological process
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	IBA	biological process
GO:0071028	nuclear mRNA surveillance	IBA	biological process
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	IBA	biological process
GO:0004532	exoribonuclease activity	IDA	NOT|molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0000178	exosome (RNase complex)	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0006364	rRNA processing	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0003723	RNA binding	IEA	molecular function
GO:0006364	rRNA processing	TAS	biological process
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	TAS	biological process
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005654	nucleoplasm	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0043488	regulation of mRNA stability	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005730	nucleolus	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000178	exosome (RNase complex)	IDA	cellular component
GO:0000178	exosome (RNase complex)	TAS	cellular component
GO:0006364	rRNA processing	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0006401	RNA catabolic process	NAS	biological process
GO:0003723	RNA binding	TAS	molecular function
GO:0000175	3'-5'-exoribonuclease activity	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03018	RNA degradation

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq