• Gene id: 22925

Gene Summary

• Gene Symbol: PLA2R1   Gene   UCSC   Ensembl
• Aliases: CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R
• Gene name: phospholipase A2 receptor 1
• Alternate names: secretory phospholipase A2 receptor, 180 kDa secretory phospholipase A2 receptor, C-type lectin domain family 13 member C, M-type receptor, phospholipase A2 receptor 1, 180kD, phospholipase A2 receptor 1, 180kDa,
• Gene location: 2q24.2 (160062614: 159932001)     Exons: 11     NC_000002.12
• Gene summary(Entrez): This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms
• OMIM: 604939

Protein Summary

• Protein general information: Q13018  
  • Name: Secretory phospholipase A2 receptor (PLA2 R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C type lectin domain family 13 member C) (M type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2 R) (Soluble PLA2R)]
  • Length: 1463  
  • Mass: 168600
  • Tissue specificity: Present in lung macrophage (at protein level). Highly expressed in kidney. Also expressed in pancreas, amnion, choriodecidua and placenta. Isoform 2 is expressed at much lower level. {ECO
• Sequence:

  MLLSPSLLLLLLLGAPRGCAEGVAAALTPERLLEWQDKGIFVIQSESLKKCIQAGKSVLTLENCKQANKHMLWKW
  VSNHGLFNIGGSGCLGLNFSAPEQPLSLYECDSTLVSLRWRCNRKMITGPLQYSVQVAHDNTVVASRKYIHKWIS
  YGSGGGDICEYLHKDLHTIKGNTHGMPCMFPFQYNHQWHHECTREGREDDLLWCATTSRYERDEKWGFCPDPTSA
  EVGCDTIWEKDLNSHICYQFNLLSSLSWSEAHSSCQMQGGTLLSITDETEENFIREHMSSKTVEVWMGLNQLDEH
  AGWQWSDGTPLNYLNWSPEVNFEPFVEDHCGTFSSFMPSAWRSRDCESTLPYICKKYLNHIDHEIVEKDAWKYYA
  THCEPGWNPYNRNCYKLQKEEKTWHEALRSCQADNSALIDITSLAEVEFLVTLLGDENASETWIGLSSNKIPVSF
  EWSNDSSVIFTNWHTLEPHIFPNRSQLCVSAEQSEGHWKVKNCEERLFYICKKAGHVLSDAESGCQEGWERHGGF
  CYKIDTVLRSFDQASSGYYCPPALVTITNRFEQAFITSLISSVVKMKDSYFWIALQDQNDTGEYTWKPVGQKPEP
  VQYTHWNTHQPRYSGGCVAMRGRHPLGRWEVKHCRHFKAMSLCKQPVENQEKAEYEERWPFHPCYLDWESEPGLA
  SCFKVFHSEKVLMKRTWREAEAFCEEFGAHLASFAHIEEENFVNELLHSKFNWTEERQFWIGFNKRNPLNAGSWE
  WSDRTPVVSSFLDNTYFGEDARNCAVYKANKTLLPLHCGSKREWICKIPRDVKPKIPFWYQYDVPWLFYQDAEYL
  FHTFASEWLNFEFVCSWLHSDLLTIHSAHEQEFIHSKIKALSKYGASWWIGLQEERANDEFRWRDGTPVIYQNWD
  TGRERTVNNQSQRCGFISSITGLWGSEECSVSMPSICKRKKVWLIEKKKDTPKQHGTCPKGWLYFNYKCLLLNIP
  KDPSSWKNWTHAQHFCAEEGGTLVAIESEVEQAFITMNLFGQTTSVWIGLQNDDYETWLNGKPVVYSNWSPFDII
  NIPSHNTTEVQKHIPLCALLSSNPNFHFTGKWYFEDCGKEGYGFVCEKMQDTSGHGVNTSDMYPMPNTLEYGNRT
  YKIINANMTWYAAIKTCLMHKAQLVSITDQYHQSFLTVVLNRLGYAHWIGLFTTDNGLNFDWSDGTKSSFTFWKD
  EESSLLGDCVFADSNGRWHSTACESFLQGAICHVPPETRQSEHPELCSETSIPWIKFKSNCYSFSTVLDSMSFEA
  AHEFCKKEGSNLLTIKDEAENAFLLEELFAFGSSVQMVWLNAQFDGNNETIKWFDGTPTDQSNWGIRKPDTDYFK
  PHHCVALRIPEGLWQLSPCQEKKGFICKMEADIHTAEALPEKGPSHSIIPLAVVLTLIVIVAICTLSFCIYKHNG
  GFFRRLAGFRNPYYPATNFSTVYLEENILISDLEKSDQ

• Structural information:
  • Protein Domains: (38..16-)
    lectin (/note="Ricin-B-type)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00174-)
    (173..22-)
    (/note="Fibronectin-type-II)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00479-)
    (238..35-)
    1 (/note="C-type-lectin)
    (/evidence="ECO:0-)
  • Interpro: IPR001304  IPR016186  IPR018378  IPR016187  IPR000562   IPR036943  IPR035992  IPR000772  
  • Prosite: PS00615 PS50041 PS00023 PS51092 PS50231
  • CDD: cd00062 cd00161
  • PDB: 6JLI
  • PDBsum: 6JLI
  • STRING: ENSP00000283243
• Other Databases: GeneCards:  PLA2R1  Malacards:  PLA2R1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0038023	signaling receptor activity	IBA	molecular function
GO:0043235	receptor complex	IBA	cellular component
GO:0005886	plasma membrane	IBA	cellular component
GO:1904635	positive regulation of glomerular visceral epithelial cell apoptotic process	IMP	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0030246	carbohydrate binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0016020	membrane	IEA	cellular component
GO:0006897	endocytosis	IEA	biological process
GO:0016021	integral component of membrane	IEA	cellular component
GO:0043235	receptor complex	IDA	cellular component
GO:0090238	positive regulation of arachidonic acid secretion	IEA	biological process
GO:0043274	phospholipase binding	IEA	molecular function
GO:0006898	receptor-mediated endocytosis	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0005886	plasma membrane	IEA	cellular component
GO:0005886	plasma membrane	IDA	cellular component
GO:0072593	reactive oxygen species metabolic process	IDA	biological process
GO:0009986	cell surface	IDA	cellular component
GO:0090238	positive regulation of arachidonic acid secretion	ISS	biological process
GO:0005576	extracellular region	ISS	cellular component
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP	biological process
GO:0090403	oxidative stress-induced premature senescence	IMP	biological process
GO:0090399	replicative senescence	IMP	biological process
GO:1900139	negative regulation of arachidonic acid secretion	ISS	biological process
GO:1900138	negative regulation of phospholipase A2 activity	ISS	biological process
GO:0001816	cytokine production	IMP	biological process

KEGG pathways

Pathway id	Pathway name
hsa05152	Tuberculosis
hsa04145	Phagosome

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881