Gene id |
22924 |
Gene Summary Protein Summary Gene ontology Diseases PubMed |
Gene Summary
|
Gene Symbol |
MAPRE3 Gene UCSC Ensembl |
Aliases |
EB3, EBF3, EBF3-S, RP3 |
Gene name |
microtubule associated protein RP/EB family member 3 |
Alternate names |
microtubule-associated protein RP/EB family member 3, APC binding protein, EB1 protein family member 3, end-binding protein 3, |
Gene location |
2p23.3 (26970636: 27027218) Exons: 9 NC_000002.12
|
Gene summary(Entrez) |
The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. [provided by RefSeq, Jul 2008]
|
OMIM |
605788 |
Protein Summary
|
Protein general information
| Q9UPY8
Name: Microtubule associated protein RP/EB family member 3 (EB1 protein family member 3) (EBF3) (End binding protein 3) (EB3) (RP3)
Length: 281 Mass: 31982
Tissue specificity: Predominantly expressed in brain and muscle. {ECO
|
Sequence |
MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNF KVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSK KLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHETDAQILELNQQLVDLKLTVDGLEKERDF YFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY
|
Structural information |
|
Other Databases |
GeneCards: MAPRE3 Malacards: MAPRE3 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0008022 |
protein C-terminus bindin g
|
IPI |
molecular function |
GO:0019901 |
protein kinase binding
|
IPI |
molecular function |
GO:0045860 |
positive regulation of pr otein kinase activity
|
IDA |
biological process |
GO:0008104 |
protein localization
|
TAS |
biological process |
GO:0031113 |
regulation of microtubule polymerization
|
IMP |
biological process |
GO:0008017 |
microtubule binding
|
IBA |
molecular function |
GO:0031110 |
regulation of microtubule polymerization or depoly merization
|
IBA |
biological process |
GO:1904825 |
protein localization to m icrotubule plus-end
|
IBA |
biological process |
GO:0005815 |
microtubule organizing ce nter
|
IBA |
cellular component |
GO:0005874 |
microtubule
|
IBA |
cellular component |
GO:0035371 |
microtubule plus-end
|
IBA |
cellular component |
GO:0035372 |
protein localization to m icrotubule
|
IBA |
biological process |
GO:0051010 |
microtubule plus-end bind ing
|
IBA |
molecular function |
GO:0051225 |
spindle assembly
|
IBA |
biological process |
GO:0051233 |
spindle midzone
|
IBA |
cellular component |
GO:0008017 |
microtubule binding
|
IEA |
molecular function |
GO:0051301 |
cell division
|
IEA |
biological process |
GO:0007049 |
cell cycle
|
IEA |
biological process |
GO:0005874 |
microtubule
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0005856 |
cytoskeleton
|
IEA |
cellular component |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0042802 |
identical protein binding
|
IPI |
molecular function |
GO:0042802 |
identical protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0045893 |
positive regulation of tr anscription, DNA-template d
|
IEA |
biological process |
GO:0015630 |
microtubule cytoskeleton
|
IEA |
cellular component |
GO:0008017 |
microtubule binding
|
IEA |
molecular function |
GO:1903033 |
positive regulation of mi crotubule plus-end bindin g
|
IEA |
biological process |
GO:0045737 |
positive regulation of cy clin-dependent protein se rine/threonine kinase act ivity
|
IEA |
biological process |
GO:0035371 |
microtubule plus-end
|
IEA |
cellular component |
GO:0030496 |
midbody
|
IEA |
cellular component |
GO:0005874 |
microtubule
|
IEA |
cellular component |
GO:0005737 |
cytoplasm
|
IEA |
cellular component |
GO:0008017 |
microtubule binding
|
ISS |
molecular function |
GO:0045893 |
positive regulation of tr anscription, DNA-template d
|
ISS |
biological process |
GO:0005737 |
cytoplasm
|
ISS |
cellular component |
GO:0030496 |
midbody
|
ISS |
cellular component |
GO:0045737 |
positive regulation of cy clin-dependent protein se rine/threonine kinase act ivity
|
ISS |
biological process |
GO:0005856 |
cytoskeleton
|
IEA |
cellular component |
GO:1905721 |
mitotic spindle astral mi crotubule end
|
IDA |
cellular component |
|
|
Associated diseases |
References |
Spermatogenic defects | MIK: 31037746 |
Teratozoospermia | MIK: 17327269 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
17327269 |
Teratozoos permia
|
|
|
19 (6 controls , 13 cases)
|
Male infertility |
GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
|
Show abstract |
31037746 |
Spermatoge nic defect s
|
|
|
16 (1 control, 15 cases)
|
Male infertility |
GSE6023 analyzed using GEO2R
|
Show abstract |
|