• Gene id: 22904

Gene Summary

• Gene Symbol: SBNO2   Gene   UCSC   Ensembl
• Aliases: KIAA0963, SNO, STNO
• Gene name: strawberry notch homolog 2
• Alternate names: protein strawberry notch homolog 2,
• Gene location: 19p13.3 (1174267: 1107636)     Exons: 33     NC_000019.10
• OMIM: 615729

Protein Summary

• Protein general information: Q9Y2G9  
  • Name: Protein strawberry notch homolog 2
  • Length: 1366  
  • Mass: 150275
  • Tissue specificity: Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. {ECO
• Sequence:

  MLAVGPAMDRDYPQHEPPPAGSLLYSPPPLQSAMLHCPYWNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPDTSY
  APVATASSLPPKTCDFAQDSSYFEDFSNISIFSSSVDSLSDIVDTPDFLPADSLNQVSTIWDDNPAPSTHDKLFQ
  LSRPFAGFEDFLPSHSTPLLVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQHPDRVVETST
  LSSVPPPDITYTLALPSDSGALSALQLEAITYACQQHEVLLPSGQRAGFLIGDGAGVGKGRTVAGVILENHLRGR
  KKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYGDTTTSEGVLFATYSALIGESQAGGQHRTRLRQILDW
  CGEAFEGVIVFDECHKAKNAGSTKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEE
  FLHAIEKRGVGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWIG
  LESRKSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLGENDGHLNCFVSAA
  EGVFLSLIQKHFPSTKRKRDRGAGSKRKRRPRGRGAKAPRLACETAGVIRISDDSSTESDPGLDSDFNSSPESLV
  DDDVVIVDAVGLPSDDRGPLCLLQRDPHGPGVLERVERLKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEM
  TGRKGRVVSRPDGTVAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTL
  ELPWSADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSKYNFENK
  YGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVGIGGRESRNGCLDVEKDCSITKFLNRILGL
  EVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEIYEESQQVFLAPGHPQDGQVVFYKISVDRGLKW
  EDAFAKSLALTGPYDGFYLSYKVRGNKPSCLLAEQNRGQFFTVYKPNIGRQSQLEALDSLRRKFHRVTAEEAKEP
  WESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMADVSSSSYLQIVRLKTKD
  RKKQVGIKIPEGCVRRVLQELRLMDADVKRRQAPALGCPAPPAPRPLALPCGPGEVLDLTYSPPAEAFPPPPHFS
  FPAPLSLDAGPGVVPLGTPDAQADPAALAHQGCDINFKEVLEDMLRSLHAGPPSEGALGEGAGAGGAAGGGPERQ
  SVIQFSPPFPGAQAPL

• Structural information:
  • Interpro: IPR027417  IPR030410  IPR026937  IPR026741  IPR039187  
  • STRING: ENSP00000354733
• Other Databases: GeneCards:  SBNO2  Malacards:  SBNO2

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0050727	regulation of inflammatory response	IBA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IBA	biological process
GO:0042393	histone binding	IBA	molecular function
GO:0071354	cellular response to interleukin-6	IBA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	biological process
GO:0031490	chromatin DNA binding	IBA	molecular function
GO:0030316	osteoclast differentiation	IBA	biological process
GO:0006355	regulation of transcription, DNA-templated	IBA	biological process
GO:0005634	nucleus	IBA	cellular component
GO:0002281	macrophage activation involved in immune response	IBA	biological process
GO:0071354	cellular response to interleukin-6	IDA	biological process
GO:0071348	cellular response to interleukin-11	ISS	biological process
GO:0071222	cellular response to lipopolysaccharide	ISS	biological process
GO:1990830	cellular response to leukemia inhibitory factor	ISS	biological process
GO:0050727	regulation of inflammatory response	IEA	biological process
GO:0006355	regulation of transcription, DNA-templated	IEA	biological process
GO:0030154	cell differentiation	IEA	biological process
GO:0001503	ossification	IEA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IEA	biological process
GO:0050727	regulation of inflammatory response	IEA	biological process
GO:0061430	bone trabecula morphogenesis	IEA	biological process
GO:0071222	cellular response to lipopolysaccharide	IEA	biological process
GO:0071348	cellular response to interleukin-11	IEA	biological process
GO:0072674	multinuclear osteoclast differentiation	IEA	biological process
GO:0072675	osteoclast fusion	IEA	biological process
GO:0002281	macrophage activation involved in immune response	IEA	biological process
GO:0030282	bone mineralization	IEA	biological process
GO:0030316	osteoclast differentiation	IEA	biological process
GO:0045944	positive regulation of transcription by RNA polymerase II	IEA	biological process
GO:0071354	cellular response to interleukin-6	IEA	biological process
GO:1990830	cellular response to leukemia inhibitory factor	IEA	biological process
GO:0045892	negative regulation of transcription, DNA-templated	IMP	biological process
GO:0005575	cellular_component	ND	cellular component
GO:0050727	regulation of inflammatory response	IMP	biological process
GO:0002281	macrophage activation involved in immune response	IMP	biological process

Diseases

Associated diseases	References
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq