• Gene id: 22824

Gene Summary

• Gene Symbol: HSPA4L   Gene   UCSC   Ensembl
• Aliases: APG-1, HSPH3, Osp94
• Gene name: heat shock protein family A (Hsp70) member 4 like
• Alternate names: heat shock 70 kDa protein 4L, heat shock 70 kDa protein 4-like protein, heat shock 70-related protein APG-1, heat shock 70kDa protein 4-like, heat shock protein (hsp110 family), osmotic stress protein 94, testis tissue sperm-binding protein Li 64n,
• Gene location: 4q28.1 (127781795: 127840732)     Exons: 22     NC_000016.10
• Gene summary(Entrez): The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a goo
• OMIM: 0

KEGG pathways

Pathway id	Pathway name
hsa04141	Protein processing in endoplasmic reticulum

Diseases

Associated diseases	References
Osteoporosis	GAD: 17903295
Non obstructive azoospermia	MIK: 29528137
Sperm quality defects	MIK: 27356588
Nonobstructive azoospermia	MIK: 29528137
Male infertility	MIK: 27356588
Spermatogenic defects	MIK: 31037746
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
27356588	Sperm quality, Male infertility				Male infertility
29528137	Nonobstructive azoospermia			21 (14 nonobstructive azoospermic men (N = 4; normal FSH and normal testicular volume and N = 10; high FSH and small testicular volume), seven normozoospermic men)	Male infertility
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray