• Gene id: 22808

Gene Summary

• Gene Symbol: MRAS   Gene   UCSC   Ensembl
• Aliases: M-RAs, NS11, R-RAS3, RRAS3
• Gene name: muscle RAS oncogene homolog
• Alternate names: ras-related protein M-Ras, muscle and microspikes RAS, ras-related protein R-Ras3,
• Gene location: 3q22.3 (138347647: 138405534)     Exons: 10     NC_000003.12
• Gene summary(Entrez): This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with m
• OMIM: 609185

Protein Summary

• Protein general information: O14807  
  • Name: Ras related protein M Ras (Ras related protein R Ras3)
  • Length: 208  
  • Mass: 23846
  • Tissue specificity: Expression highly restricted to the brain and heart.
• Sequence:

  MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDPTIEDSYLKHTEIDNQWAILDVLDTAGQEEFS
  AMREQYMRTGDGFLIVYSVTDKASFEHVDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNI
  PYIETSAKDPPLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL

• Structural information:
  • Interpro: IPR027417  IPR005225  IPR001806  IPR020849  
  • Prosite: PS51421
  • DIP: 35406
  • STRING: ENSP00000289104
• Other Databases: GeneCards:  MRAS  Malacards:  MRAS

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005525	GTP binding	IBA	molecular function
GO:0003924	GTPase activity	IBA	molecular function
GO:0019003	GDP binding	IBA	molecular function
GO:0007265	Ras protein signal transduction	IBA	biological process
GO:0005886	plasma membrane	IBA	cellular component
GO:0003924	GTPase activity	IMP	molecular function
GO:0007265	Ras protein signal transduction	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0003924	GTPase activity	IEA	molecular function
GO:0005525	GTP binding	IEA	molecular function
GO:0007165	signal transduction	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0005525	GTP binding	IEA	molecular function
GO:0005886	plasma membrane	IEA	cellular component
GO:0000166	nucleotide binding	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0003924	GTPase activity	TAS	molecular function
GO:0007265	Ras protein signal transduction	TAS	biological process
GO:0007517	muscle organ development	TAS	biological process
GO:0030036	actin cytoskeleton organization	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0007275	multicellular organism development	TAS	biological process
GO:1990830	cellular response to leukemia inhibitory factor	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0030742	GTP-dependent protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04010	MAPK signaling pathway
hsa04014	Ras signaling pathway
hsa04810	Regulation of actin cytoskeleton
hsa04015	Rap1 signaling pathway
hsa05205	Proteoglycans in cancer
hsa04072	Phospholipase D signaling pathway
hsa04140	Autophagy - animal
hsa04371	Apelin signaling pathway
hsa04218	Cellular senescence
hsa04625	C-type lectin receptor signaling pathway
hsa04137	Mitophagy - animal

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq