• Gene id: 2266

Gene Summary

• Gene Symbol: FGG   Gene   UCSC   Ensembl
• Gene name: fibrinogen gamma chain
• Alternate names: fibrinogen gamma chain, fibrinogen, gamma polypeptide, testicular tissue protein Li 70,
• Gene location: 4q32.1 (154612807: 154604133)     Exons: 10     NC_000004.12
• Gene summary(Entrez): The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most ab
• OMIM: 134850

Protein Summary

• Protein general information: P02679  
  • Name: Fibrinogen gamma chain
  • Length: 453  
  • Mass: 51512
  • Tissue specificity: Detected in blood plasma (at protein level). {ECO
• Sequence:

  MSWSLHPRNLILYFYALLFLSSTCVAYVATRDNCCILDERFGSYCPTTCGIADFLSTYQTKVDKDLQSLEDILHQ
  VENKTSEVKQLIKAIQLTYNPDESSKPNMIDAATLKSRKMLEEIMKYEASILTHDSSIRYLQEIYNSNNQKIVNL
  KEKVAQLEAQCQEPCKDTVQIHDITGKDCQDIANKGAKQSGLYFIKPLKANQQFLVYCEIDGSGNGWTVFQKRLD
  GSVDFKKNWIQYKEGFGHLSPTGTTEFWLGNEKIHLISTQSAIPYALRVELEDWNGRTSTADYAMFKVGPEADKY
  RLTYAYFAGGDAGDAFDGFDFGDDPSDKFFTSHNGMQFSTWDNDNDKFEGNCAEQDGSGWWMNKCHAGHLNGVYY
  QGGTYSKASTPNGYDNGIIWATWKTRWYSMKKTTMKIIPFNRLTIGEGQQHHLGGAKQVRPEHPAETEYDSLYPE
  DDL

• Structural information:
  • Protein Domains: (170..41-)
    (/note="Fibrinogen-C-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00739"-)
  • Interpro: IPR036056  IPR014716  IPR014715  IPR002181  IPR012290   IPR020837  IPR037581  
  • Prosite: PS00514 PS51406
  • CDD: cd00087
  • PDB: 1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60
  • PDBsum: 1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS 4B60
  • DIP: 29644
  • STRING: ENSP00000336829
• Other Databases: GeneCards:  FGG  Malacards:  FGG

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005577	fibrinogen complex	IDA	cellular component
GO:0062023	collagen-containing extracellular matrix	IBA	cellular component
GO:0007160	cell-matrix adhesion	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0072378	blood coagulation, fibrin clot formation	IBA	biological process
GO:0070527	platelet aggregation	IBA	biological process
GO:0005102	signaling receptor binding	IBA	molecular function
GO:0005577	fibrinogen complex	IEA	cellular component
GO:0007596	blood coagulation	IEA	biological process
GO:0030168	platelet activation	IEA	biological process
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0051258	protein polymerization	IEA	biological process
GO:0007599	hemostasis	IEA	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0002224	toll-like receptor signaling pathway	TAS	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0030198	extracellular matrix organization	TAS	biological process
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0044267	cellular protein metabolic process	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0007596	blood coagulation	TAS	biological process
GO:0043687	post-translational protein modification	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0036345	platelet maturation	IEA	biological process
GO:0042802	identical protein binding	IEA	molecular function
GO:0071347	cellular response to interleukin-1	IEA	biological process
GO:0071354	cellular response to interleukin-6	IEA	biological process
GO:0072562	blood microparticle	IEA	cellular component
GO:0090331	negative regulation of platelet aggregation	IEA	biological process
GO:0005198	structural molecule activity	IDA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005577	fibrinogen complex	IDA	cellular component
GO:0007160	cell-matrix adhesion	IDA	biological process
GO:0090277	positive regulation of peptide hormone secretion	IDA	biological process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA	biological process
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0034116	positive regulation of heterotypic cell-cell adhesion	IDA	biological process
GO:0034622	cellular protein-containing complex assembly	IDA	biological process
GO:0045907	positive regulation of vasoconstriction	IDA	biological process
GO:0045921	positive regulation of exocytosis	IDA	biological process
GO:0050714	positive regulation of protein secretion	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0070374	positive regulation of ERK1 and ERK2 cascade	IDA	biological process
GO:0070527	platelet aggregation	IDA	biological process
GO:2000352	negative regulation of endothelial cell apoptotic process	IDA	biological process
GO:0051258	protein polymerization	IMP	biological process
GO:0005102	signaling receptor binding	IPI	molecular function
GO:0050839	cell adhesion molecule binding	IPI	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	HDA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005201	extracellular matrix structural constituent	RCA	molecular function
GO:0005615	extracellular space	IDA	cellular component
GO:0051592	response to calcium ion	IDA	biological process
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	NAS	biological process
GO:0009897	external side of plasma membrane	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0031091	platelet alpha granule	IDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0031639	plasminogen activation	IDA	biological process
GO:0005577	fibrinogen complex	IDA	cellular component
GO:0072378	blood coagulation, fibrin clot formation	IDA	biological process
GO:0042730	fibrinolysis	IDA	biological process
GO:0005577	fibrinogen complex	IDA	cellular component
GO:0005577	fibrinogen complex	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0009306	protein secretion	IMP	biological process
GO:0072378	blood coagulation, fibrin clot formation	IMP	biological process
GO:0005615	extracellular space	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0072562	blood microparticle	HDA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04611	Platelet activation
hsa05150	Staphylococcus aureus infection
hsa04610	Complement and coagulation cascades

Diseases

Associated diseases	References
Inherited thrombophilia	KEGG:H00223
Afibrinogenemia	KEGG:H00222
Inherited thrombophilia	KEGG:H00223
Afibrinogenemia	KEGG:H00222
Congenital afibrinogenemia	PMID:15284111
type 2 diabetes mellitus	PMID:7974333
multiple myeloma	PMID:22348216
Aberrant CpGs in Low Motility Sperm	MIK: 21674046
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
21674046	Aberrant CpGs in Low Motility Sperm			18	Male infertility	GSE26881