• Gene id: 221711

Gene Summary

• Gene Symbol: SYCP2L   Gene   UCSC   Ensembl
• Aliases: C6orf177, NO145, dJ62D2.1
• Gene name: synaptonemal complex protein 2 like
• Alternate names: synaptonemal complex protein 2-like, 145 kDa nucleolar protein homolog, SCP-2-like,
• Gene location: 6p24.2 (10887051: 10974308)     Exons: 30     NC_000006.12
• OMIM: 602402

Protein Summary

• Protein general information: Q5T4T6  
  • Name: Synaptonemal complex protein 2 like (SCP 2 like) (145 kDa nucleolar protein homolog) (hsNO145)
  • Length: 812  
  • Mass: 93599
  • Tissue specificity: Expressed in the ovary (at protein level). {ECO
• Sequence:

  MQAKNKDALQPIKEDRTGKAQDDAFWLQSLITDAFHDKGFQKIKEYFQQKESHFPQKYNRLLLYRLDRSINKELD
  KNEFQSVSLLLKCIQRFLVDGLKEDEPLLIRQGLIPKLVSWFERTTGILTSEGLASDTSLICVIEDFFDTALIIS
  RSSSEGKIQMLDSFLLSLGFLVTEKTVNHLLQQEGLKTFNCILHAVPREERKKFPLSEGMCHLMKDLARTLLTVG
  DYDQQVAISEALCRLTIKKSRDELVHKWFDDEVIAEAFKEIKDREFETDSRRFLNHLNNRLGDQRRVYSFPCIAA
  FADEHEMRKPADEKLEKFWIDFNLGSQSVTFYIDNAENTLWDSVTLPKEAVMNFSITETEKIKIFIIYLKKPMII
  SYKEVMKIEIHFDLQFNISQVSIQALGEDKQMLPDQTKISSELFSKSDKEDRESPSGLERETEQAEESTNMVEFM
  SAEDDRCLITLHLNDQSEPPVIGEPASDSHLQPVPPFGVPDFPQQPKSHYRKHLFSESNQDSSTSELSWTSNQKK
  KSLKSYSSRKKTRTRSNLRILPVFPPSSGSGHEKDQAKLLSPSEKEIPEQNNTTSPKTSEQKFQDSFAFLTAEDS
  AQKTELQDPHSLSELSSLKHSEDEEKPKIVNQESLTESTSLKHKLRNLEDKDIPEGSFAKSQQSRLEEEVAPGSP
  FSITEERELPEGISTSSLEVVPENLNGSAILPTFENFTKKRKRKYELRYRKRPFNSENAKKAPDCLIKLLNQMQL
  FRLNKLERFQNLVLQELSSLKQDIQALEHLEKEVLEFWGKQSADLQSFCDLQVLRFNSTQTS

• Structural information:
  • Interpro: IPR024835  IPR041322  IPR040560  
  • STRING: ENSP00000283141
• Other Databases: GeneCards:  SYCP2L  Malacards:  SYCP2L

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000800	lateral element	IBA	cellular component
GO:0140013	meiotic nuclear division	IBA	biological process
GO:0000780	condensed nuclear chromosome, centromeric region	IBA	cellular component
GO:0000780	condensed nuclear chromosome, centromeric region	IDA	cellular component
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0005694	chromosome	IEA	cellular component
GO:0005634	nucleus	IEA	cellular component
GO:0000775	chromosome, centromeric region	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray