• Gene id: 221395

Gene Summary

• Gene Symbol: ADGRF5   Gene   UCSC   Ensembl
• Aliases: GPR116, KPG_001
• Gene name: adhesion G protein-coupled receptor F5
• Alternate names: adhesion G protein-coupled receptor F5, G-protein coupled receptor 116, Ig-Hepta homolog, probable G-protein coupled receptor 116,
• Gene location: 6p12.3 (46954953: 46852521)     Exons: 25     NC_000006.12
• OMIM: 613081

Protein Summary

• Protein general information: Q8IZF2  
  • Name: Adhesion G protein coupled receptor F5 (G protein coupled receptor 116)
  • Length: 1346  
  • Mass: 149457
• Sequence:

  MKSPRRTTLCLMFIVIYSSKAALNWNYESTIHPLSLHEHEPAGEEALRQKRAVATKSPTAEEYTVNIEISFENAS
  FLDPIKAYLNSLSFPIHGNNTDQITDILSINVTTVCRPAGNEIWCSCETGYGWPRERCLHNLICQERDVFLPGHH
  CSCLKELPPNGPFCLLQEDVTLNMRVRLNVGFQEDLMNTSSALYRSYKTDLETAFRKGYGILPGFKGVTVTGFKS
  GSVVVTYEVKTTPPSLELIHKANEQVVQSLNQTYKMDYNSFQAVTINESNFFVTPEIIFEGDTVSLVCEKEVLSS
  NVSWRYEEQQLEIQNSSRFSIYTALFNNMTSVSKLTIHNITPGDAGEYVCKLILDIFEYECKKKIDVMPIQILAN
  EEMKVMCDNNPVSLNCCSQGNVNWSKVEWKQEGKINIPGTPETDIDSSCSRYTLKADGTQCPSGSSGTTVIYTCE
  FISAYGARGSANIKVTFISVANLTITPDPISVSEGQNFSIKCISDVSNYDEVYWNTSAGIKIYQRFYTTRRYLDG
  AESVLTVKTSTREWNGTYHCIFRYKNSYSIATKDVIVHPLPLKLNIMVDPLEATVSCSGSHHIKCCIEEDGDYKV
  TFHTGSSSLPAAKEVNKKQVCYKHNFNASSVSWCSKTVDVCCHFTNAANNSVWSPSMKLNLVPGENITCQDPVIG
  VGEPGKVIQKLCRFSNVPSSPESPIGGTITYKCVGSQWEEKRNDCISAPINSLLQMAKALIKSPSQDEMLPTYLK
  DLSISIDKAEHEISSSPGSLGAIINILDLLSTVPTQVNSEMMTHVLSTVNVILGKPVLNTWKVLQQQWTNQSSQL
  LHSVERFSQALQSGDSPPLSFSQTNVQMSSMVIKSSHPETYQQRFVFPYFDLWGNVVIDKSYLENLQSDSSIVTM
  AFPTLQAILAQDIQENNFAESLVMTTTVSHNTTMPFRISMTFKNNSPSGGETKCVFWNFRLANNTGGWDSSGCYV
  EEGDGDNVTCICDHLTSFSILMSPDSPDPSSLLGILLDIISYVGVGFSILSLAACLVVEAVVWKSVTKNRTSYMR
  HTCIVNIAASLLVANTWFIVVAAIQDNRYILCKTACVAATFFIHFFYLSVFFWMLTLGLMLFYRLVFILHETSRS
  TQKAIAFCLGYGCPLAISVITLGATQPREVYTRKNVCWLNWEDTKALLAFAIPALIIVVVNITITIVVITKILRP
  SIGDKPCKQEKSSLFQISKSIGVLTPLLGLTWGFGLTTVFPGTNLVFHIIFAILNVFQGLFILLFGCLWDLKVQE
  ALLNKFSLSRWSSQHSKSTSLGSSTPVFSMSSPISRRFNNLFGKTGTYNVSTPEATSSSLENSSSASSLLN

• Structural information:
  • Protein Domains: (166..27-)
    (/note="SEA-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00188-)
    (267..36-)
    (/note="Ig-like-1)
    (369..46-)
    (/note="Ig-like-2)
    (471..56-)
    (/note="Ig-like-3)
    (951..100-)
    (/note="GPS-)
    (/evidence="ECO:0000255|PROSIT-)
  • Interpro: IPR017981  IPR008078  IPR000832  IPR017983  IPR000203   IPR007110  IPR036179  IPR013783  IPR003599  IPR003598  IPR000082  IPR036364  
  • Prosite: PS00650 PS50261 PS50221 PS50835 PS50024
  • STRING: ENSP00000283296
• Other Databases: GeneCards:  ADGRF5  Malacards:  ADGRF5

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004888	transmembrane signaling receptor activity	IEA	molecular function
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0007166	cell surface receptor signaling pathway	IEA	biological process
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007165	signal transduction	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component
GO:0004930	G protein-coupled receptor activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0007186	G protein-coupled receptor signaling pathway	IEA	biological process
GO:0031410	cytoplasmic vesicle	IDA	cellular component
GO:0009986	cell surface	IDA	cellular component
GO:0004930	G protein-coupled receptor activity	TAS	molecular function
GO:0007186	G protein-coupled receptor signaling pathway	TAS	biological process
GO:0016021	integral component of membrane	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0043031	negative regulation of macrophage activation	IEA	biological process
GO:0006112	energy reserve metabolic process	IEA	biological process
GO:0071073	positive regulation of phospholipid biosynthetic process	IEA	biological process
GO:0061626	pharyngeal arch artery morphogenesis	IEA	biological process
GO:0048821	erythrocyte development	IEA	biological process
GO:0045444	fat cell differentiation	IEA	biological process
GO:0045177	apical part of cell	IEA	cellular component
GO:0043129	surfactant homeostasis	IEA	biological process
GO:0042593	glucose homeostasis	IEA	biological process
GO:0019216	regulation of lipid metabolic process	IEA	biological process
GO:0003094	glomerular filtration	IEA	biological process
GO:0005886	plasma membrane	IEA	cellular component

Diseases

Associated diseases	References
Cryptorchidism	MIK: 28606200

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq