Gene id |
2208 |
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed |
Gene Summary
|
Gene Symbol |
FCER2 Gene UCSC Ensembl |
Aliases |
BLAST-2, CD23, CD23A, CLEC4J, FCE2, IGEBF |
Gene name |
Fc fragment of IgE receptor II |
Alternate names |
low affinity immunoglobulin epsilon Fc receptor, C-type lectin domain family 4, member J, CD23 antigen, Fc epsilon receptor II, Fc fragment of IgE, low affinity II, receptor for (CD23), fc-epsilon-RII, immunoglobulin E-binding factor, immunoglobulin epsilon-chai, |
Gene location |
19p13.2 (7702754: 7688756) Exons: 12 NC_000019.10
|
Gene summary(Entrez) |
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, the
|
OMIM |
607263 |
Protein Summary
|
Protein general information
| P06734
Name: Low affinity immunoglobulin epsilon Fc receptor (BLAST 2) (C type lectin domain family 4 member J) (Fc epsilon RII) (Immunoglobulin E binding factor) (Lymphocyte IgE receptor) (CD antigen CD23) [Cleaved into: Low affinity immunoglobulin epsilon Fc recepto
Length: 321 Mass: 36469
|
Sequence |
MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHH GDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRM ELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRN LDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESM GPDSRPDPDGRLPTPSAPLHS
|
Structural information |
|
Other Databases |
GeneCards: FCER2 Malacards: FCER2 |
|
GO accession | Term name | Evidence code | Go category |
---|
GO:0046872 |
metal ion binding
|
IEA |
molecular function |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0016020 |
membrane
|
IEA |
cellular component |
GO:0019863 |
IgE binding
|
IEA |
molecular function |
GO:0030246 |
carbohydrate binding
|
IEA |
molecular function |
GO:0016021 |
integral component of mem brane
|
IEA |
cellular component |
GO:0005178 |
integrin binding
|
TAS |
molecular function |
GO:0005887 |
integral component of pla sma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0005886 |
plasma membrane
|
TAS |
cellular component |
GO:0007219 |
Notch signaling pathway
|
TAS |
biological process |
GO:0019221 |
cytokine-mediated signali ng pathway
|
TAS |
biological process |
GO:0019221 |
cytokine-mediated signali ng pathway
|
TAS |
biological process |
GO:0005515 |
protein binding
|
IPI |
molecular function |
GO:0009897 |
external side of plasma m embrane
|
IEA |
cellular component |
GO:0002925 |
positive regulation of hu moral immune response med iated by circulating immu noglobulin
|
IEA |
biological process |
GO:0051712 |
positive regulation of ki lling of cells of other o rganism
|
IDA |
biological process |
GO:0051000 |
positive regulation of ni tric-oxide synthase activ ity
|
IDA |
biological process |
GO:0051770 |
positive regulation of ni tric-oxide synthase biosy nthetic process
|
IDA |
biological process |
GO:0005576 |
extracellular region
|
IEA |
cellular component |
GO:0005886 |
plasma membrane
|
IEA |
cellular component |
GO:0070062 |
extracellular exosome
|
HDA |
cellular component |
GO:0070062 |
extracellular exosome
|
HDA |
cellular component |
|
|
Pathway id | Pathway name |
hsa05169 | Epstein-Barr virus infection | hsa04640 | Hematopoietic cell lineage | |
|
Associated diseases |
References |
Cryptorchidism | MIK: 28606200 |
|
|
PMID |
Condition |
Mutation |
Ethnicity |
Population details |
Infertility_type |
Associated_genes |
Abstract |
28606200 |
Cryptorchi dism
|
|
|
Monozgotic twin s (1 control, I cwith cryptorc hidism)
|
Male infertility |
MeDIP-Seq
|
Show abstract |
|