• Gene id: 2203

Gene Summary

• Gene Symbol: FBP1   Gene   UCSC   Ensembl
• Aliases: FBP
• Gene name: fructose-bisphosphatase 1
• Alternate names: fructose-1,6-bisphosphatase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, FBPase 1, growth-inhibiting protein 17, liver FBPase,
• Gene location: 9q22.32 (115147287: 114314499)     Exons: 25     NC_000003.12
• Gene summary(Entrez): Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic
• OMIM: 611570

Protein Summary

• Protein general information: P09467  
  • Name: Fructose 1,6 bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D fructose 1,6 bisphosphate 1 phosphohydrolase 1) (Liver FBPase)
  • Length: 338  
  • Mass: 36842
  • Tissue specificity: Expressed in pancreatic islets. {ECO
• Sequence:

  MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLD
  VLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSE
  KDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVT
  EYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
  EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ

• Structural information:
  • Interpro: IPR000146  IPR033391  IPR028343  IPR020548  
  • Prosite: PS00124
  • CDD: cd00354
  • PDB: 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B
  • PDBsum: 1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B
  • DIP: 46677
  • STRING: ENSP00000408025
• Other Databases: GeneCards:  FBP1  Malacards:  FBP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005737	cytoplasm	IBA	cellular component
GO:0005986	sucrose biosynthetic process	IBA	biological process
GO:0006002	fructose 6-phosphate metabolic process	IBA	biological process
GO:0030388	fructose 1,6-bisphosphate metabolic process	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0006000	fructose metabolic process	IBA	biological process
GO:0006094	gluconeogenesis	IBA	biological process
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IBA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IEA	molecular function
GO:0016791	phosphatase activity	IEA	molecular function
GO:0042578	phosphoric ester hydrolase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0006094	gluconeogenesis	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0005975	carbohydrate metabolic process	IEA	biological process
GO:0003824	catalytic activity	IEA	molecular function
GO:0006000	fructose metabolic process	TAS	biological process
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IEA	molecular function
GO:0005829	cytosol	TAS	cellular component
GO:0006094	gluconeogenesis	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0006094	gluconeogenesis	IEA	biological process
GO:0001085	RNA polymerase II transcription factor binding	IMP	molecular function
GO:0005634	nucleus	IMP	cellular component
GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	biological process
GO:0045820	negative regulation of glycolytic process	IMP	biological process
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IDA	molecular function
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IDA	molecular function
GO:0035690	cellular response to drug	IDA	biological process
GO:0035690	cellular response to drug	IDA	biological process
GO:0030308	negative regulation of cell growth	IDA	biological process
GO:0016311	dephosphorylation	IDA	biological process
GO:0071286	cellular response to magnesium ion	IDA	biological process
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IDA	molecular function
GO:0016311	dephosphorylation	IDA	biological process
GO:0046580	negative regulation of Ras protein signal transduction	IDA	biological process
GO:0045820	negative regulation of glycolytic process	IDA	biological process
GO:0016208	AMP binding	IDA	molecular function
GO:0006002	fructose 6-phosphate metabolic process	IDA	biological process
GO:0016208	AMP binding	IDA	molecular function
GO:0016208	AMP binding	IDA	molecular function
GO:0006002	fructose 6-phosphate metabolic process	IDA	biological process
GO:0005737	cytoplasm	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0046872	metal ion binding	IMP	molecular function
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IMP	molecular function
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IMP	molecular function
GO:0006094	gluconeogenesis	ISS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0048029	monosaccharide binding	ISS	molecular function
GO:0006111	regulation of gluconeogenesis	IMP	biological process
GO:0070062	extracellular exosome	HDA	cellular component
GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity	IMP	molecular function
GO:0016311	dephosphorylation	IMP	biological process
GO:0006094	gluconeogenesis	IMP	biological process
GO:0006094	gluconeogenesis	IMP	biological process
GO:0005829	cytosol	ISS	cellular component
GO:0042802	identical protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function

KEGG pathways

Pathway id	Pathway name
hsa01100	Metabolic pathways
hsa04910	Insulin signaling pathway
hsa01200	Carbon metabolism
hsa04152	AMPK signaling pathway
hsa04922	Glucagon signaling pathway
hsa00010	Glycolysis / Gluconeogenesis
hsa00051	Fructose and mannose metabolism
hsa00030	Pentose phosphate pathway

Diseases

Associated diseases	References
Fructose-1,6-bisphosphatase deficiency	KEGG:H00114
Fructose-1,6-bisphosphatase deficiency	KEGG:H00114
Fructose-1,6-bisphosphatase deficiency	PMID:7763253
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)