• Gene id: 220002

Gene Summary

• Gene Symbol: CYB561A3   Gene   UCSC   Ensembl
• Aliases: CYBASC3, LCYTB
• Gene name: cytochrome b561 family member A3
• Alternate names: cytochrome b ascorbate-dependent protein 3, cytochrome b, ascorbate dependent 3, lysosomal cytochrome b,
• Gene location: 11q12.2 (61362282: 61348744)     Exons: 8     NC_000011.10
• OMIM: 618757

Protein Summary

• Protein general information: Q8NBI2  
  • Name: Cytochrome b ascorbate dependent protein 3 (EC 1. . . ) (Cytochrome b561 family member A3) (Lysosomal cytochrome b) (LCytb)
  • Length: 242  
  • Mass: 27214
• Sequence:

  MVSGRFYLSCLLLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGP
  KLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRS
  LLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKR
  PEPGILTDRQPLLHDGE

• Structural information:
  • Protein Domains: (12..21-)
    (/note="Cytochrome-b561)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00242"-)
  • Interpro: IPR006593  
  • Prosite: PS50939
  • STRING: ENSP00000389745
• Other Databases: GeneCards:  CYB561A3  Malacards:  CYB561A3

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005765	lysosomal membrane	IBA	cellular component
GO:0016491	oxidoreductase activity	IBA	molecular function
GO:0031902	late endosome membrane	ISS	cellular component
GO:0005765	lysosomal membrane	ISS	cellular component
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0005768	endosome	IEA	cellular component
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0005764	lysosome	IEA	cellular component
GO:0046872	metal ion binding	IEA	molecular function
GO:0055114	oxidation-reduction process	IEA	biological process
GO:0016491	oxidoreductase activity	IEA	molecular function
GO:0016020	membrane	IEA	cellular component
GO:0016021	integral component of membrane	IEA	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0031902	late endosome membrane	IEA	cellular component
GO:0005765	lysosomal membrane	IEA	cellular component
GO:0005654	nucleoplasm	IDA	cellular component
GO:0043231	intracellular membrane-bounded organelle	IDA	cellular component
GO:0005730	nucleolus	IDA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0005765	lysosomal membrane	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)