• Gene id: 219595

Gene Summary

• Gene Symbol: FOLH1B   Gene   UCSC   Ensembl
• Aliases: FOLH2, FOLHP, GCP3, GCPIII, PSM, PSMA-LIKE, PSMAL
• Gene name: folate hydrolase 1B
• Alternate names: putative N-acetylated-alpha-linked acidic dipeptidase, N-acetylated-alpha-linked-acidic dipeptidase, NAALADase, cell growth-inhibiting gene 26 protein, folate hydrolase 2, folate hydrolase pseudogene, glutamate carboxypeptidase III, prostate-specific membrane an,
• Gene location: 11q14.3 (89637579: 89698717)     Exons: 19     NC_000011.10
• OMIM: 609020

Protein Summary

• Protein general information: Q9HBA9  
  • Name: Putative N acetylated alpha linked acidic dipeptidase (NAALADase) (EC 3.4. . ) (Cell growth inhibiting gene 26 protein) (Prostate specific membrane antigen like protein) (Putative folate hydrolase 1B)
  • Length: 442  
  • Mass: 50045
  • Tissue specificity: Kidney and liver. Not expressed in the prostate. {ECO
• Sequence:

  MGGSAPPDSSWRGSLKVSYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIGTLRGAVEPDRYVILGGHRDSWVF
  GGIDPQSGAAVVHETVRSFGTLKKEGWRPRRTILFASWDAEEFGLLGSTEWAEDNSRLLQERGVAYINADSSIEG
  NYTLRVDCTPLMYSLVYNLTKELKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASG
  RARYTKNWETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDYAVVLRKYA
  DKIYNISMKHPQEMKTYSLSFDSLFSAVKNFTEIASKFSERLQDFDKSNPILLRMMNDQLMFLERAFIDPLGLPD
  RPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVDPSKAWGDVKRQISVAAFTVQAAAETLSEVA

• Structural information:
  • Interpro: IPR007484  IPR039373  IPR007365  IPR036757  
• Other Databases: GeneCards:  FOLH1B  Malacards:  FOLH1B

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004180	carboxypeptidase activity	IBA	molecular function
GO:0005886	plasma membrane	IBA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0008152	metabolic process	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0016805	dipeptidase activity	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0003824	catalytic activity	IEA	molecular function
GO:0008237	metallopeptidase activity	IEA	molecular function
GO:0005886	plasma membrane	TAS	cellular component
GO:0008652	cellular amino acid biosynthetic process	TAS	biological process
GO:0004181	metallocarboxypeptidase activity	IDA	molecular function
GO:0035609	C-terminal protein deglutamylation	IDA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)