• Gene id: 2159

Gene Summary

• Gene Symbol: F10   Gene   UCSC   Ensembl
• Aliases: FX, FXA
• Gene name: coagulation factor X
• Alternate names: coagulation factor X, Stuart-Prower factor, factor X, factor Xa, prothrombinase,
• Gene location: 13q34 (113122798: 113149528)     Exons: 8     NC_000013.11
• Gene summary(Entrez): This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two ch
• OMIM: 613872

Protein Summary

• Protein general information: P00742  
  • Name: Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
  • Length: 488  
  • Mass: 54,732
• Sequence:

  MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSD
  KTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCS
  CARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQP
  ERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
  AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQST
  RLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYG
  IYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK

• Structural information:
  • Protein Domains: Gla. (41-85)
    EGF-like (86-122)
    ({ECO:0000255|PROSITE-ProRule:PRU00076}-)
    EGF-like (125-165)
    Peptidase (235-467)
  • Interpro: IPR017857  IPR001881  IPR013032  IPR000742  IPR000152   IPR018097  IPR035972  IPR000294  IPR012224  IPR009003  IPR001314  IPR001254  IPR018114  IPR033116  
  • Prosite: PS00010 PS00022 PS01186 PS50026 PS01187 PS00011 PS50998 PS50240 PS00134 PS00135
  • CDD: cd00190
  • PDB: 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8
  • PDBsum: 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1WU1 1XKA 1XKB 1Z6E 2BMG 2BOH 2BOK 2BQ6 2BQ7 2BQW 2CJI 2D1J 2EI6 2EI7 2EI8
  • DIP: 29896
  • STRING: ENSP00000364709
• Other Databases: GeneCards:  F10  Malacards:  F10

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004252	serine-type endopeptidase activity	IMP	molecular function
GO:0004252	serine-type endopeptidase activity	IDA	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	IDA	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006465	signal peptide processing	TAS	biological process
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	biological process
GO:0007596	blood coagulation	IC	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007597	blood coagulation, intrinsic pathway	TAS	biological process
GO:0007598	blood coagulation, extrinsic pathway	TAS	biological process
GO:0017187	peptidyl-glutamic acid carboxylation	TAS	biological process
GO:0030335	positive regulation of cell migration	TAS	biological process
GO:0031233	intrinsic component of external side of plasma membrane	IC	cellular component
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0004252	serine-type endopeptidase activity	IMP	molecular function
GO:0004252	serine-type endopeptidase activity	IDA	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	IDA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006465	signal peptide processing	TAS	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0006508	proteolysis	IEA	biological process
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0007596	blood coagulation	IC	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007597	blood coagulation, intrinsic pathway	TAS	biological process
GO:0007598	blood coagulation, extrinsic pathway	TAS	biological process
GO:0007599	hemostasis	IEA	biological process
GO:0008233	peptidase activity	IEA	molecular function
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0017187	peptidyl-glutamic acid carboxylation	TAS	biological process
GO:0030335	positive regulation of cell migration	TAS	biological process
GO:0031233	intrinsic component of external side of plasma membrane	IC	cellular component
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0004252	serine-type endopeptidase activity	IMP	molecular function
GO:0004252	serine-type endopeptidase activity	IDA	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005543	phospholipid binding	IDA	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006465	signal peptide processing	TAS	biological process
GO:0006888	ER to Golgi vesicle-mediated transport	TAS	biological process
GO:0007596	blood coagulation	IC	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007596	blood coagulation	TAS	biological process
GO:0007597	blood coagulation, intrinsic pathway	TAS	biological process
GO:0007598	blood coagulation, extrinsic pathway	TAS	biological process
GO:0017187	peptidyl-glutamic acid carboxylation	TAS	biological process
GO:0030335	positive regulation of cell migration	TAS	biological process
GO:0031233	intrinsic component of external side of plasma membrane	IC	cellular component
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process

KEGG pathways

Pathway id	Pathway name
hsa04610	Complement and coagulation cascades

Diseases

Associated diseases	References
Apoplexy	GAD: 20198315
Cardiovascular disease	GAD: 18974842
Hypertension	GAD: 19851296
Alzheimer's disease	GAD: 19141999
Kidney diseases	GAD: 19724895
Chronic renal failure	GAD: 21085059
Male factor infertility	MIK: 18591887
Hypogonadotropic hypogonadism	MIK: 18591887
Hypogonadotropic hypogonadism	MIK: 18591887
Teratozoospermia	MIK: 17327269
Unexplained infertility	MIK: 25753583

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
18591887	Idiopathic hypogonadotropic hypogonadism			37 (17 IHH, 20 controls)	Male infertility	FV FX and AT III
18591887	Idiopathic hypogonadotropic hypogonadism (IHH)			37 (17 with IHH, 20 age-matched healthy controls)	Male infertility	FV FX ATIII
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
25753583	Unexplained infertility			46 (17 fertile men, 29 male patients)	Male infertility	Microarray