• Gene id: 2155

Gene Summary

• Gene Symbol: F7   Gene   UCSC   Ensembl
• Aliases: SPCA
• Gene name: coagulation factor VII
• Alternate names: coagulation factor VII, FVII coagulation protein, coagulation factor VII (serum prothrombin conversion accelerator), eptacog alfa, proconvertin,
• Gene location: 13q34 (23049671: 23045632)     Exons: 1     NC_000020.11
• Gene summary(Entrez): This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by
• OMIM: 613878

Protein Summary

• Protein general information: P08709  
  • Name: Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
  • Length: 466  
  • Mass: 51594
  • Tissue specificity: Plasma.
• Sequence:

  MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRRANAFLEELRPGSLER
  ECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLI
  CVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECP
  WQVLLLVNGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
  HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVLNVPRLMTQDCLQQSR
  KVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQKL
  MRSEPRPGVLLRAPFP

• Structural information:
  • Protein Domains: (61..10-)
    (/note="Gla-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00463-)
    (106..14-)
    (/note="EGF-like-)
    (-)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00076-)
    (147..18-)
    (/note="EGF-like-2)
    (/evidence="ECO:0000255|PROSIT-)
  • Interpro: IPR017857  IPR001881  IPR013032  IPR000742  IPR000152   IPR018097  IPR033190  IPR035972  IPR000294  IPR012224  IPR009003  IPR001314  IPR001254  IPR018114  IPR033116  
  • Prosite: PS00010 PS00022 PS01186 PS50026 PS01187 PS00011 PS50998 PS50240 PS00134 PS00135
  • CDD: cd00190
  • PDB: 1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT
  • PDBsum: 1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT
  • DIP: 6135
  • STRING: ENSP00000364731
• Other Databases: GeneCards:  F7  Malacards:  F7

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0007596	blood coagulation	IBA	biological process
GO:0005615	extracellular space	IBA	cellular component
GO:0002690	positive regulation of leukocyte chemotaxis	IBA	biological process
GO:0004252	serine-type endopeptidase activity	IEA	molecular function
GO:0005509	calcium ion binding	IEA	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0006508	proteolysis	IEA	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0007596	blood coagulation	IEA	biological process
GO:0016787	hydrolase activity	IEA	molecular function
GO:0007599	hemostasis	IEA	biological process
GO:0005576	extracellular region	IEA	cellular component
GO:0008233	peptidase activity	IEA	molecular function
GO:0006508	proteolysis	IEA	biological process
GO:0008236	serine-type peptidase activity	IEA	molecular function
GO:0004252	serine-type endopeptidase activity	TAS	molecular function
GO:0008236	serine-type peptidase activity	TAS	molecular function
GO:0005576	extracellular region	TAS	cellular component
GO:0007596	blood coagulation	TAS	biological process
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0005886	plasma membrane	TAS	cellular component
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	TAS	biological process
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005788	endoplasmic reticulum lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0005796	Golgi lumen	TAS	cellular component
GO:0007598	blood coagulation, extrinsic pathway	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0007596	blood coagulation	IEA	biological process
GO:0001666	response to hypoxia	IEA	biological process
GO:0005615	extracellular space	IEA	cellular component
GO:0007596	blood coagulation	IEA	biological process
GO:0014070	response to organic cyclic compound	IEA	biological process
GO:0032355	response to estradiol	IEA	biological process
GO:0043627	response to estrogen	IEA	biological process
GO:0061476	response to anticoagulant	IEA	biological process
GO:0070723	response to cholesterol	IEA	biological process
GO:0097066	response to thyroid hormone	IEA	biological process
GO:1904400	response to Thyroid stimulating hormone	IEA	biological process
GO:0004175	endopeptidase activity	IEA	molecular function
GO:0005102	signaling receptor binding	IEA	molecular function
GO:0007623	circadian rhythm	IEA	biological process
GO:0009725	response to hormone	IEA	biological process
GO:0010037	response to carbon dioxide	IEA	biological process
GO:0030194	positive regulation of blood coagulation	IEA	biological process
GO:0031100	animal organ regeneration	IEA	biological process
GO:0031667	response to nutrient levels	IEA	biological process
GO:0031982	vesicle	IEA	cellular component
GO:0032571	response to vitamin K	IEA	biological process
GO:0033595	response to genistein	IEA	biological process
GO:0060416	response to growth hormone	IEA	biological process
GO:0097068	response to thyroxine	IEA	biological process
GO:1904612	response to 2,3,7,8-tetrachlorodibenzodioxine	IEA	biological process
GO:1905217	response to astaxanthin	IEA	biological process
GO:1905225	response to thyrotropin-releasing hormone	IEA	biological process
GO:0004252	serine-type endopeptidase activity	IDA	contributes to
GO:0005515	protein binding	IPI	molecular function
GO:0002690	positive regulation of leukocyte chemotaxis	IDA	biological process
GO:0010641	positive regulation of platelet-derived growth factor receptor signaling pathway	IDA	biological process
GO:0050927	positive regulation of positive chemotaxis	IDA	biological process
GO:0030335	positive regulation of cell migration	TAS	biological process
GO:0016485	protein processing	IDA	biological process
GO:0007596	blood coagulation	IDA	biological process
GO:0051897	positive regulation of protein kinase B signaling	IDA	biological process
GO:0007596	blood coagulation	IDA	biological process
GO:0062023	collagen-containing extracellular matrix	HDA	cellular component
GO:1905286	serine-type peptidase complex	IPI	cellular component
GO:0005576	extracellular region	IEA	cellular component

KEGG pathways

Pathway id	Pathway name
hsa04610	Complement and coagulation cascades

Diseases

Associated diseases	References
Factor VII deficiency	KEGG:H02256
Factor VII deficiency	KEGG:H02256
Hypertension	PMID:8123879
Hypertension	PMID:10450539
Hereditary angioedema	PMID:9129025
Thrombocytopenia	PMID:19175492
Breast cancer	PMID:19996301
Inherited blood coagulation disease	PMID:10469179
Factor VII deficiency	PMID:26083983
Arteriosclerosis	PMID:9569183
Ovarian cancer	PMID:19904262
Coronary artery disease	PMID:8522401
Coronary artery disease	PMID:10599031
Coronary artery disease	PMID:11334615
Cerebral infarction	PMID:14733777
Cerebral infarction	PMID:21998055
Hyperglycemia	PMID:3240844
Kidney disease	PMID:15608477
Proteinuria	PMID:509177
Myocardial infarction	PMID:7495060
Myocardial infarction	PMID:9420338
intermediate coronary syndrome	PMID:10653827
Diabetic retinopathy	PMID:10837382
colorectal cancer	PMID:19062044
type 2 diabetes mellitus	PMID:17785358
type 2 diabetes mellitus	PMID:15860378
type 2 diabetes mellitus	PMID:18000605
type 2 diabetes mellitus	PMID:11689270
type 2 diabetes mellitus	PMID:10332679
Diabetic neuropathy	PMID:10468085
type 1 diabetes mellitus	PMID:15860378
type 1 diabetes mellitus	PMID:11297753
type 1 diabetes mellitus	PMID:11146704
type 1 diabetes mellitus	PMID:9686915
obesity	PMID:19329212
obesity	PMID:16739871
obesity	PMID:14513073
obesity	PMID:9258277
Cryptorchidism	MIK: 28606200
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
28606200	Cryptorchidism			Monozgotic twins (1 control, I cwith cryptorchidism)	Male infertility	MeDIP-Seq