• Gene id: 213

Gene Summary

• Gene Symbol: ALB   Gene   UCSC   Ensembl
• Aliases: HSA, PRO0883, PRO0903, PRO1341
• Gene name: albumin
• Alternate names: serum albumin,
• Gene location: 4q13.3 (73404238: 73421483)     Exons: 15     NC_000004.12
• Gene summary(Entrez): This gene encodes the most abundant protein in human blood. This protein functions in the regulation of blood plasma colloid osmotic pressure and acts as a carrier protein for a wide range of endogenous molecules including hormones, fatty acids, and metab
• OMIM: 103600

Protein Summary

• Protein general information: P02768  
  • Name: Serum albumin
  • Length: 609  
  • Mass: 69,367
• Sequence:

  MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAK
  TCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTA
  FHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCA
  SLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
  ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAK
  TYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEV
  SRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKE
  FNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
  AASQAALGL

• Structural information:
  • Protein Domains: Albumin (19-210)
    Albumin (211-403)
    Albumin (404-601)
  • Interpro: IPR000264  IPR020858  IPR021177  IPR020857  IPR014760  
  • Prosite: PS00212 PS51438
  • CDD: cd00015
  • PDB: 1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2N0X 2VDB 2VUE 2VUF
  • PDBsum: 1AO6 1BJ5 1BKE 1BM0 1E78 1E7A 1E7B 1E7C 1E7E 1E7F 1E7G 1E7H 1E7I 1GNI 1GNJ 1H9Z 1HA2 1HK1 1HK2 1HK3 1HK4 1HK5 1N5U 1O9X 1TF0 1UOR 1YSX 2BX8 2BXA 2BXB 2BXC 2BXD 2BXE 2BXF 2BXG 2BXH 2BXI 2BXK 2BXL 2BXM 2BXN 2BXO 2BXP 2BXQ 2ESG 2I2Z 2I30 2N0X 2VDB 2VUE 2VUF
  • DIP: 29902
  • STRING: ENSP00000295897
• Other Databases: GeneCards:  ALB  Malacards:  ALB

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001895	retina homeostasis	IEP	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	NAS	molecular function
GO:0005507	copper ion binding	NAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005604	basement membrane	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0006810	transport	TAS	biological process
GO:0006898	receptor-mediated endocytosis	TAS	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0008144	drug binding	NAS	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0009267	cellular response to starvation	IDA	biological process
GO:0010033	response to organic substance	IEA	biological process
GO:0015643	toxic substance binding	IDA	molecular function
GO:0015721	bile acid and bile salt transport	TAS	biological process
GO:0016209	antioxidant activity	NAS	molecular function
GO:0019836	hemolysis by symbiont of host erythrocytes	IDA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0030170	pyridoxal phosphate binding	IDA	molecular function
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0042157	lipoprotein metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043069	negative regulation of programmed cell death	NAS	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043234	protein complex	IDA	cellular component
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	IEA	biological process
GO:0046689	response to mercury ion	IEA	biological process
GO:0051087	chaperone binding	IPI	molecular function
GO:0051659	maintenance of mitochondrion location	IDA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070541	response to platinum ion	IEA	biological process
GO:0072562	blood microparticle	IDA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0019825	oxygen binding	IDA	molecular function
GO:0001895	retina homeostasis	IEP	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0005504	fatty acid binding	IEA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	NAS	molecular function
GO:0005507	copper ion binding	NAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	IEA	cellular component
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005604	basement membrane	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IEA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0006810	transport	IEA	biological process
GO:0006810	transport	TAS	biological process
GO:0006898	receptor-mediated endocytosis	TAS	biological process
GO:0007584	response to nutrient	IEA	biological process
GO:0008144	drug binding	IEA	molecular function
GO:0008144	drug binding	NAS	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008270	zinc ion binding	IEA	molecular function
GO:0008289	lipid binding	IEA	molecular function
GO:0009267	cellular response to starvation	IDA	biological process
GO:0010033	response to organic substance	IEA	biological process
GO:0015643	toxic substance binding	IDA	molecular function
GO:0015721	bile acid and bile salt transport	TAS	biological process
GO:0016209	antioxidant activity	NAS	molecular function
GO:0019836	hemolysis by symbiont of host erythrocytes	IDA	biological process
GO:0019899	enzyme binding	IEA	molecular function
GO:0030170	pyridoxal phosphate binding	IDA	molecular function
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0042157	lipoprotein metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043069	negative regulation of programmed cell death	NAS	biological process
GO:0043209	myelin sheath	IEA	cellular component
GO:0043234	protein complex	IDA	cellular component
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0046010	positive regulation of circadian sleep/wake cycle, non-REM sleep	IEA	biological process
GO:0046689	response to mercury ion	IEA	biological process
GO:0046872	metal ion binding	IEA	molecular function
GO:0051087	chaperone binding	IPI	molecular function
GO:0051659	maintenance of mitochondrion location	IDA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070541	response to platinum ion	IEA	biological process
GO:0072562	blood microparticle	IDA	cellular component
GO:0098869	cellular oxidant detoxification	IEA	biological process
GO:0019825	oxygen binding	IDA	molecular function
GO:0001895	retina homeostasis	IEP	biological process
GO:0002576	platelet degranulation	TAS	biological process
GO:0003677	DNA binding	IDA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	IDA	molecular function
GO:0005504	fatty acid binding	NAS	molecular function
GO:0005507	copper ion binding	NAS	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005576	extracellular region	NAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005576	extracellular region	TAS	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005615	extracellular space	IDA	cellular component
GO:0005634	nucleus	IDA	cellular component
GO:0005783	endoplasmic reticulum	IDA	cellular component
GO:0005794	Golgi apparatus	IDA	cellular component
GO:0006810	transport	TAS	biological process
GO:0006898	receptor-mediated endocytosis	TAS	biological process
GO:0008144	drug binding	NAS	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0008144	drug binding	IDA	molecular function
GO:0009267	cellular response to starvation	IDA	biological process
GO:0015643	toxic substance binding	IDA	molecular function
GO:0015721	bile acid and bile salt transport	TAS	biological process
GO:0016209	antioxidant activity	NAS	molecular function
GO:0019836	hemolysis by symbiont of host erythrocytes	IDA	biological process
GO:0030170	pyridoxal phosphate binding	IDA	molecular function
GO:0031093	platelet alpha granule lumen	TAS	cellular component
GO:0042157	lipoprotein metabolic process	TAS	biological process
GO:0042802	identical protein binding	IPI	molecular function
GO:0042802	identical protein binding	IPI	molecular function
GO:0043066	negative regulation of apoptotic process	IDA	biological process
GO:0043069	negative regulation of programmed cell death	NAS	biological process
GO:0043234	protein complex	IDA	cellular component
GO:0043252	sodium-independent organic anion transport	TAS	biological process
GO:0051087	chaperone binding	IPI	molecular function
GO:0051659	maintenance of mitochondrion location	IDA	biological process
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0070062	extracellular exosome	IDA	cellular component
GO:0072562	blood microparticle	IDA	cellular component
GO:0019825	oxygen binding	IDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04918	Thyroid hormone synthesis

Diseases

Associated diseases	References
Analbuminemia	OMIM: 103600
Diabetes	GAD: 12732844
Alzheimer's disease	GAD: 16536861
Attention deficit disorder conduct disorder oppositional defiant disorder	GAD: 11140838
Ovarian hyperstimulation syndrome (OHSS)	INFBASE: 22971456
Azoospermia	MIK: 1986964
Sperm morphology	MIK: 17430425
Male factor infertility	MIK: 1917683
Oligozoospermia	MIK: 1986964
Polyzoospermia	MIK: 1986964
Dysalbuminemic hyperthyroxinemia	OMIM: 103600
Azoospermia	MIK: 1986964
Polyzoospermia	MIK: 1986964
Male infertility	MIK: 1986964
Oligozoospermia	MIK: 1917683
Sperm morphology	MIK: 17430425
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
1986964	Azoospermia, oligozoospermia, polyzoospermia, Male infertility			171 (50 subjects with normal sperm count; 32 with azoospermia; 49 with oligozoospermia; 10 with polyzoospermia; and 31 vasectomized)	Male infertility	transferrin  beta 2-microglobulin and albumin
17430425	Sperm morphology			916 samples	Male infertility
1917683	Oligozoospermia				Male infertility
1986964	Azoospermia, Oligozoospermia			171 (50 subjects with normal sperm count; 32 with azoospermia; 49 with oligozoospermia; 10 with polyzoospermia; and 31 vasectomized)	Male infertility	Transferrin beta 2-microglobulin albumin
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)