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Gene id 207
Gene Summary     SNPs    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol AKT1   Gene   UCSC   Ensembl
Aliases AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Gene name AKT serine/threonine kinase 1
Alternate names RAC-alpha serine/threonine-protein kinase, AKT1m, PKB alpha, RAC-PK-alpha, protein kinase B alpha, proto-oncogene c-Akt, rac protein kinase alpha, serine-threonine protein kinase, v-akt murine thymoma viral oncogene homolog 1, v-akt murine thymoma viral o,
Gene location 14q32.33 (104795742: 104769348)     Exons: 15     NC_000014.9
Gene summary(Entrez) The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific,
OMIM 164730

SNPs
rs6461992

Strand:    Allele origin:   Allele change:   Mutation type: snv

NC_000007.14   g.27181212A>G
NC_000007.14   g.27181212A>T
NC_000007.13   g.27220831A>G
NC_000007.13   g.27220831A>T
NG_012079.1   g.9005T>C
NG_012079.1   g.9005T>A
NM_005523.6   c.*1584T>C
NM_005523.6   c.*1584T>A
NM_005523.5   c.*1584T>C
NM_005523.5   c.*1584T>A|SEQ=[A

Protein Summary
Protein general information P31749  

Name: RAC alpha serine/threonine protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto oncogene c Akt) (RAC PK alpha)

Length: 480  Mass: 55,686

Sequence MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFII
RCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEF
EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCF
VMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPE
AKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT
PPDQDDSMECVDSERRPHFPQFSYSASGTA
Structural information
Protein Domains
 PH. (5-108)
Protein (150-408)
AGC-kinase (409-480)
Interpro:  IPR000961  IPR034676  IPR011009  IPR011993  IPR001849  
IPR017892  IPR000719  IPR017441  IPR008271  
Prosite:   PS51285 PS50003 PS00107 PS50011 PS00108
CDD:   cd05594

PDB:  		 1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV
PDBsum:   1H10 1UNP 1UNQ 1UNR 2UVM 2UZR 2UZS 3CQU 3CQW 3MV5 3MVH 3O96 3OCB 3OW4 3QKK 3QKL 3QKM 4EJN 4EKK 4EKL 4GV1 5KCV

DIP:  
24269
MINT:  
STRING:   ENSP00000270202
Other Databases GeneCards:  AKT1  Malacards:  AKT1

Gene ontology

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GO accessionTerm nameEvidence codeGo category

KEGG pathways

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Pathway idPathway name
hsa04668TNF signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04024cAMP signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04150mTOR signaling pathway
hsa04140Autophagy - animal
hsa04210Apoptosis
hsa04218Cellular senescence
hsa04510Focal adhesion
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04625C-type lectin receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04062Chemokine signaling pathway
hsa04910Insulin signaling pathway
hsa04922Glucagon signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04920Adipocytokine signaling pathway
hsa04929GnRH secretion
hsa04915Estrogen signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04926Relaxin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04973Carbohydrate digestion and absorption
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04722Neurotrophin signaling pathway
hsa04380Osteoclast differentiation
hsa04211Longevity regulating pathway
hsa04213Longevity regulating pathway - multiple species
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05230Central carbon metabolism in cancer
hsa05231Choline metabolism in cancer
hsa05235PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05225Hepatocellular carcinoma
hsa05226Gastric cancer
hsa05214Glioma
hsa05221Acute myeloid leukemia
hsa05220Chronic myeloid leukemia
hsa05218Melanoma
hsa05211Renal cell carcinoma
hsa05215Prostate cancer
hsa05213Endometrial cancer
hsa05224Breast cancer
hsa05222Small cell lung cancer
hsa05223Non-small cell lung cancer
hsa05418Fluid shear stress and atherosclerosis
hsa04932Non-alcoholic fatty liver disease
hsa04931Insulin resistance
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05135Yersinia infection
hsa05152Tuberculosis
hsa05166Human T-cell leukemia virus 1 infection
hsa05170Human immunodeficiency virus 1 infection
hsa05162Measles
hsa05164Influenza A
hsa05161Hepatitis B
hsa05160Hepatitis C
hsa05168Herpes simplex virus 1 infection
hsa05163Human cytomegalovirus infection
hsa05167Kaposi sarcoma-associated herpesvirus infection
hsa05169Epstein-Barr virus infection
hsa05165Human papillomavirus infection
hsa05145Toxoplasmosis
hsa05142Chagas disease
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa01524Platinum drug resistance
hsa01522Endocrine resistance

Diseases

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Associated diseases References
PTEN hamartoma tumor syndrome KEGG: H00539
Cancer (Adenocarcinoma) GAD: 20186503
Cancer (bladder) GAD: 19692168
Cancer (colon) GAD: 20622004
Cancer (colorectal) GAD: 19219602
Cancer (endometrial) GAD: 19853286
Cancer (esophageal) GAD: 19164214
Cancer (leukemia) GAD: 19074885
Cancer (lung) GAD: 18611285
Cancer (myeloid leukemia) GAD: 19744127
Cancer (Papilary) GAD: 19487299
Cancer (prostate) GAD: 20407443
Cancer (retinal) GAD: 19420344
Cancer (breast) GAD: 20306497
Atherosclerosis GAD: 19948975
Insulin resistance GAD: 21061022
Obesity GAD: 20734064
Diabetes GAD: 11508278
Bone diseases GAD: 19453261
Meningioma KEGG: H01556
Alzheimer's disease GAD: 19141999
Parkinson disease GAD: 18395980
Major depressive disorder GAD: 20033742
Schizophrenia GAD: 16395129
Bipolar disorder GAD: 18466879
Female infertility INFBASE: 25912412
Endometriosis INFBASE: 25194152
Polycystic ovary syndrome (PCOS) INFBASE: 22455688
Varicocele MIK: 26209830
Spermatogenesis defects MIK: 26209830
Male factor infertility MIK: 26209830
Female infertility INFBASE: 19631369
Chronic obstructive pulmonary disease (COPD) GAD: 19625176
Cryptorchidism MIK: 28606200
Teratozoospermia MIK: 17327269
Varicocele MIK: 26209830
Spermatogenetic defects MIK: 26209830

PubMed references

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PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
26209830 Varicocele
37
 Male infertility
Show abstract
26209830 Varicocele
, Spermato
genetic de
fects
37 men provided
semen samples
for routine ana
lysis
 Male infertility Bad
GSK-3
HSP27
JNK/SAPK
mTOR
p38 MAPK
p53PARP
Caspase-3
Akt
Stat1 and p70 S6 kinase
 Show abstract
17327269 Teratozoos
permia
19 (6 controls
, 13 cases)
 Male infertility GSE6872 analyzed by GEO2R (cutoff 1.5 fold)
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract