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Gene id 2064
Gene Summary    Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed    

Gene Summary
Gene Symbol ERBB2   Gene   UCSC   Ensembl
Aliases CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Gene name erb-b2 receptor tyrosine kinase 2
Alternate names receptor tyrosine-protein kinase erbB-2, c-erb B2/neu protein, herstatin, human epidermal growth factor receptor 2, metastatic lymph node gene 19 protein, neuro/glioblastoma derived oncogene homolog, neuroblastoma/glioblastoma derived oncogene homolog, p1,
Gene location 17q12 (39688083: 39728661)     Exons: 32     NC_000017.11
Gene summary(Entrez) This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-boun
OMIM 164870

Protein Summary
Protein general information P04626  

Name: Receptor tyrosine protein kinase erbB 2 (EC 2.7.10.1) (Metastatic lymph node gene 19 protein) (MLN 19) (Proto oncogene Neu) (Proto oncogene c ErbB 2) (Tyrosine kinase type cell surface receptor HER2) (p185erbB2) (CD antigen CD340)

Length: 1255  Mass: 137,910

Sequence MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQ
DIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILK
GGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCA
RCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLA
FLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGI
SWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGP
TQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARC
PSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILI
KRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPV
AIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNW
CMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSE
FSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPAPGAGGMVHHRHRSS
STRSGGGDLTLGLEPSEEEAPRSPLAPSEGAGSDVFDGDLGMGAAKGLQSLPTHDPSPLQRYSEDPTVPLPSETD
GYVAPLTCSPQPEYVNQPDVRPQPPSPREGPLPAARPAGATLERPKTLSPGKNGVVKDVFAFGGAVENPEYLTPQ
GGAAPQPHPPPAFSPAFDNLYYWDQDPPERGAPPSTFKGTPTAENPEYLGLDVPV
Structural information
Protein Domains
 Protein (720-987)
Interpro:  IPR006211  IPR006212  IPR032778  IPR009030  IPR011009  
IPR000719  IPR017441  IPR000494  IPR036941  IPR001245  IPR008266  IPR020635  IPR016245  
Prosite:   PS00107 PS50011 PS00109

PDB:  		 1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5OB4 5TQS
PDBsum:   1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 2N2A 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 3WLW 3WSQ 4GFU 4HRL 4HRM 4HRN 5K33 5KWG 5MY6 5OB4 5TQS

DIP:  
8
MINT:  
STRING:   ENSP00000269571
Other Databases GeneCards:  ERBB2  Malacards:  ERBB2

Gene ontology

Expand All | Collapse All
GO accessionTerm nameEvidence codeGo category
GO:0000165 MAPK cascade
 TAS biological process
GO:0001042 RNA polymerase I core bin
ding
 IDA molecular function
GO:0001934 positive regulation of pr
otein phosphorylation
 ISS biological process
GO:0004713 protein tyrosine kinase a
ctivity
 IDA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IGI molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
 IDA molecular function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
 IEA molecular function
GO:0004888 transmembrane signaling r
eceptor activity
 IDA molecular function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
 TAS molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005524 ATP binding
 IEA molecular function
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005737 cytoplasm
 IDA cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 NAS cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0006351 transcription, DNA-templa
ted
 IEA biological process
GO:0006468 protein phosphorylation
 TAS biological process
GO:0007165 signal transduction
 IDA biological process
GO:0007166 cell surface receptor sig
naling pathway
 IDA biological process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
 TAS biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 IDA biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 TAS biological process
GO:0007422 peripheral nervous system
development
 IEA biological process
GO:0007507 heart development
 IEA biological process
GO:0007528 neuromuscular junction de
velopment
 IEA biological process
GO:0008022 protein C-terminus bindin
g
 IPI molecular function
GO:0008045 motor neuron axon guidanc
e
 IEA biological process
GO:0008283 cell proliferation
 TAS biological process
GO:0010008 endosome membrane
 IDA cellular component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
 IDA biological process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
 TAS biological process
GO:0016021 integral component of mem
brane
 NAS cellular component
GO:0016323 basolateral plasma membra
ne
 IDA cellular component
GO:0016324 apical plasma membrane
 IEA cellular component
GO:0018108 peptidyl-tyrosine phospho
rylation
 IEA biological process
GO:0019903 protein phosphatase bindi
ng
 IPI molecular function
GO:0030307 positive regulation of ce
ll growth
 IMP biological process
GO:0031410 cytoplasmic vesicle
 IEA cellular component
GO:0032886 regulation of microtubule
-based process
 IDA biological process
GO:0033088 negative regulation of im
mature T cell proliferati
on in thymus
 IEA biological process
GO:0038128 ERBB2 signaling pathway
 TAS biological process
GO:0042060 wound healing
 IDA biological process
GO:0042552 myelination
 IEA biological process
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0043125 ErbB-3 class receptor bin
ding
 TAS molecular function
GO:0043209 myelin sheath
 IEA cellular component
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 TAS cellular component
GO:0043406 positive regulation of MA
P kinase activity
 IDA biological process
GO:0043547 positive regulation of GT
Pase activity
 ISS biological process
GO:0045727 positive regulation of tr
anslation
 IMP biological process
GO:0045765 regulation of angiogenesi
s
 NAS biological process
GO:0045785 positive regulation of ce
ll adhesion
 IDA biological process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
 IMP biological process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
 IDA biological process
GO:0046777 protein autophosphorylati
on
 IDA biological process
GO:0046854 phosphatidylinositol phos
phorylation
 IEA biological process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
 TAS molecular function
GO:0046982 protein heterodimerizatio
n activity
 IDA molecular function
GO:0046982 protein heterodimerizatio
n activity
 IPI molecular function
GO:0046983 protein dimerization acti
vity
 NAS molecular function
GO:0048015 phosphatidylinositol-medi
ated signaling
 TAS biological process
GO:0048471 perinuclear region of cyt
oplasm
 IEA cellular component
GO:0048709 oligodendrocyte different
iation
 IEA biological process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
 IDA biological process
GO:0070372 regulation of ERK1 and ER
K2 cascade
 IMP biological process
GO:0071363 cellular response to grow
th factor stimulus
 IDA biological process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
 IDA biological process
GO:2000145 regulation of cell motili
ty
 TAS biological process
GO:0019838 growth factor binding
 IDA molecular function
GO:0000165 MAPK cascade
 TAS biological process
GO:0000166 nucleotide binding
 IEA molecular function
GO:0001042 RNA polymerase I core bin
ding
 IDA molecular function
GO:0001934 positive regulation of pr
otein phosphorylation
 IEA biological process
GO:0001934 positive regulation of pr
otein phosphorylation
 ISS biological process
GO:0004672 protein kinase activity
 IEA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IEA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IEA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IDA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IGI molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
 IEA molecular function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
 IEA molecular function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
 IDA molecular function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
 IEA molecular function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
 TAS molecular function
GO:0004888 transmembrane signaling r
eceptor activity
 IDA molecular function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
 TAS molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005524 ATP binding
 IEA molecular function
GO:0005524 ATP binding
 IEA molecular function
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 IEA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IEA cellular component
GO:0005737 cytoplasm
 IDA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:0005886 plasma membrane
 IEA cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 NAS cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0006351 transcription, DNA-templa
ted
 IEA biological process
GO:0006355 regulation of transcripti
on, DNA-templated
 IEA biological process
GO:0006468 protein phosphorylation
 IEA biological process
GO:0006468 protein phosphorylation
 TAS biological process
GO:0007165 signal transduction
 IDA biological process
GO:0007166 cell surface receptor sig
naling pathway
 IDA biological process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
 TAS biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 IEA biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 IDA biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 TAS biological process
GO:0007399 nervous system developmen
t
 IEA biological process
GO:0007422 peripheral nervous system
development
 IEA biological process
GO:0007507 heart development
 IEA biological process
GO:0007528 neuromuscular junction de
velopment
 IEA biological process
GO:0008022 protein C-terminus bindin
g
 IPI molecular function
GO:0008045 motor neuron axon guidanc
e
 IEA biological process
GO:0008283 cell proliferation
 TAS biological process
GO:0010008 endosome membrane
 IDA cellular component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
 IDA biological process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
 TAS biological process
GO:0016020 membrane
 IEA cellular component
GO:0016020 membrane
 IEA cellular component
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0016021 integral component of mem
brane
 IEA cellular component
GO:0016021 integral component of mem
brane
 NAS cellular component
GO:0016301 kinase activity
 IEA molecular function
GO:0016310 phosphorylation
 IEA biological process
GO:0016323 basolateral plasma membra
ne
 IDA cellular component
GO:0016324 apical plasma membrane
 IEA cellular component
GO:0016740 transferase activity
 IEA molecular function
GO:0018108 peptidyl-tyrosine phospho
rylation
 IEA biological process
GO:0019903 protein phosphatase bindi
ng
 IPI molecular function
GO:0030307 positive regulation of ce
ll growth
 IMP biological process
GO:0031410 cytoplasmic vesicle
 IEA cellular component
GO:0032886 regulation of microtubule
-based process
 IDA biological process
GO:0033088 negative regulation of im
mature T cell proliferati
on in thymus
 IEA biological process
GO:0038128 ERBB2 signaling pathway
 TAS biological process
GO:0042060 wound healing
 IDA biological process
GO:0042552 myelination
 IEA biological process
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0043125 ErbB-3 class receptor bin
ding
 TAS molecular function
GO:0043209 myelin sheath
 IEA cellular component
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 TAS cellular component
GO:0043406 positive regulation of MA
P kinase activity
 IDA biological process
GO:0043547 positive regulation of GT
Pase activity
 IEA biological process
GO:0043547 positive regulation of GT
Pase activity
 ISS biological process
GO:0045727 positive regulation of tr
anslation
 IMP biological process
GO:0045765 regulation of angiogenesi
s
 NAS biological process
GO:0045785 positive regulation of ce
ll adhesion
 IDA biological process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
 IMP biological process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
 IDA biological process
GO:0046777 protein autophosphorylati
on
 IDA biological process
GO:0046854 phosphatidylinositol phos
phorylation
 IEA biological process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
 TAS molecular function
GO:0046982 protein heterodimerizatio
n activity
 IDA molecular function
GO:0046982 protein heterodimerizatio
n activity
 IPI molecular function
GO:0046983 protein dimerization acti
vity
 NAS molecular function
GO:0048015 phosphatidylinositol-medi
ated signaling
 TAS biological process
GO:0048471 perinuclear region of cyt
oplasm
 IEA cellular component
GO:0048709 oligodendrocyte different
iation
 IEA biological process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
 IDA biological process
GO:0070372 regulation of ERK1 and ER
K2 cascade
 IMP biological process
GO:0071363 cellular response to grow
th factor stimulus
 IDA biological process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
 IDA biological process
GO:2000145 regulation of cell motili
ty
 TAS biological process
GO:0019838 growth factor binding
 IDA molecular function
GO:0000165 MAPK cascade
 TAS biological process
GO:0001042 RNA polymerase I core bin
ding
 IDA molecular function
GO:0001934 positive regulation of pr
otein phosphorylation
 ISS biological process
GO:0004713 protein tyrosine kinase a
ctivity
 IDA molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 IGI molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004713 protein tyrosine kinase a
ctivity
 TAS molecular function
GO:0004714 transmembrane receptor pr
otein tyrosine kinase act
ivity
 IDA molecular function
GO:0004716 signal transducer, downst
ream of receptor, with pr
otein tyrosine kinase act
ivity
 TAS molecular function
GO:0004888 transmembrane signaling r
eceptor activity
 IDA molecular function
GO:0005088 Ras guanyl-nucleotide exc
hange factor activity
 TAS molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005515 protein binding
 IPI molecular function
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005634 nucleus
 IDA cellular component
GO:0005737 cytoplasm
 IDA cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 NAS cellular component
GO:0005886 plasma membrane
 IDA cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0005886 plasma membrane
 TAS cellular component
GO:0006468 protein phosphorylation
 TAS biological process
GO:0007165 signal transduction
 IDA biological process
GO:0007166 cell surface receptor sig
naling pathway
 IDA biological process
GO:0007167 enzyme linked receptor pr
otein signaling pathway
 TAS biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 IDA biological process
GO:0007169 transmembrane receptor pr
otein tyrosine kinase sig
naling pathway
 TAS biological process
GO:0008022 protein C-terminus bindin
g
 IPI molecular function
GO:0008283 cell proliferation
 TAS biological process
GO:0010008 endosome membrane
 IDA cellular component
GO:0014065 phosphatidylinositol 3-ki
nase signaling
 IDA biological process
GO:0014066 regulation of phosphatidy
linositol 3-kinase signal
ing
 TAS biological process
GO:0016021 integral component of mem
brane
 NAS cellular component
GO:0016323 basolateral plasma membra
ne
 IDA cellular component
GO:0019903 protein phosphatase bindi
ng
 IPI molecular function
GO:0030307 positive regulation of ce
ll growth
 IMP biological process
GO:0032886 regulation of microtubule
-based process
 IDA biological process
GO:0038128 ERBB2 signaling pathway
 TAS biological process
GO:0042060 wound healing
 IDA biological process
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0042802 identical protein binding
 IPI molecular function
GO:0043125 ErbB-3 class receptor bin
ding
 TAS molecular function
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 IDA cellular component
GO:0043235 receptor complex
 TAS cellular component
GO:0043406 positive regulation of MA
P kinase activity
 IDA biological process
GO:0043547 positive regulation of GT
Pase activity
 ISS biological process
GO:0045727 positive regulation of tr
anslation
 IMP biological process
GO:0045765 regulation of angiogenesi
s
 NAS biological process
GO:0045785 positive regulation of ce
ll adhesion
 IDA biological process
GO:0045943 positive regulation of tr
anscription from RNA poly
merase I promoter
 IMP biological process
GO:0045945 positive regulation of tr
anscription from RNA poly
merase III promoter
 IDA biological process
GO:0046777 protein autophosphorylati
on
 IDA biological process
GO:0046934 phosphatidylinositol-4,5-
bisphosphate 3-kinase act
ivity
 TAS molecular function
GO:0046982 protein heterodimerizatio
n activity
 IDA molecular function
GO:0046982 protein heterodimerizatio
n activity
 IPI molecular function
GO:0046983 protein dimerization acti
vity
 NAS molecular function
GO:0048015 phosphatidylinositol-medi
ated signaling
 TAS biological process
GO:0050679 positive regulation of ep
ithelial cell proliferati
on
 IDA biological process
GO:0070372 regulation of ERK1 and ER
K2 cascade
 IMP biological process
GO:0071363 cellular response to grow
th factor stimulus
 IDA biological process
GO:0090314 positive regulation of pr
otein targeting to membra
ne
 IDA biological process
GO:2000145 regulation of cell motili
ty
 TAS biological process
GO:0019838 growth factor binding
 IDA molecular function

KEGG pathways

Expand All | Collapse All

Pathway idPathway name
hsa04066HIF-1 signaling pathway
hsa04020Calcium signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04530Tight junction
hsa05200Pathways in cancer
hsa05206MicroRNAs in cancer
hsa05205Proteoglycans in cancer
hsa05230Central carbon metabolism in cancer
hsa05212Pancreatic cancer
hsa05226Gastric cancer
hsa05219Bladder cancer
hsa05215Prostate cancer
hsa05213Endometrial cancer
hsa05224Breast cancer
hsa05223Non-small cell lung cancer
hsa01521EGFR tyrosine kinase inhibitor resistance
hsa01524Platinum drug resistance
hsa01522Endocrine resistance

Diseases

Expand All | Collapse All
Associated diseases References
Cancer GAD: 20026098
Cancer (bladder) GAD: 11106692
Cancer (brain) GAD: 20446891
Cancer (cervical) GAD: 16445653
Cancer (colorectal) GAD: 19504444
Cancer (endometrial) GAD: 17164260
Cancer (epithelial ovarian) GAD: 19064572
Cancer (esophageal) GAD: 19339270
Cancer (gastric) GAD: 14520697
Cancer (lung) GAD: 16003726
Cancer (ovarian) GAD: 16112085
Cancer (pancreatic) GAD: 19351817
Cancer (prostate) GAD: 15389808
Cancer (Squamous cell) GAD: 19812598
Cancer (bladder) GAD: 11857355
Cancer (stomach) GAD: 14520697
Cancer (Fallopian tube) GAD: H01554
Cancer (breast) GAD: 15550452
Cancer (oral) GAD: 12915878
Cancer (Salivary gland) GAD: H01508
Cancer (breast) GAD: 12166652
Cleft defects GAD: 18978678
Chronic renal failure GAD: 21085059
Female infertility INFBASE: 18987482
Endometriosis INFBASE: 7650146
Polycystic ovary syndrome (PCOS) INFBASE: 26416764
Endometriosis INFBASE: 18987482
Spermatogenesis defects MIK: 21550039
Chronic obstructive pulmonary disease (COPD) GAD: 19625176
Aberrant CpGs in Low Motility Sperm MIK: 21674046
Cryptorchidism MIK: 28606200
Spermatogenic defects MIK: 21550039

PubMed references

Expand All | Collapse All
PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
21550039 Spermatoge
nic defect
s

Male infertility
Show abstract
21674046 Aberrant C
pGs in Low
Motility
Sperm
18
 Male infertility GSE26881
 Show abstract
28606200 Cryptorchi
dism
Monozgotic twin
s (1 control, I
cwith cryptorc
hidism)
 Male infertility MeDIP-Seq
 Show abstract