• Gene id: 200035

Gene Summary

• Gene Symbol: NUDT17   Gene   UCSC   Ensembl
• Gene name: nudix hydrolase 17
• Alternate names: nucleoside diphosphate-linked moiety X motif 17, nudix (nucleoside diphosphate linked moiety X)-type motif 17, nudix motif 17,
• Gene location: 1q21.1 (145844984: 145848953)     Exons: 11     NC_000001.11

Protein Summary

• Protein general information: P0C025  
  • Name: Nucleoside diphosphate linked moiety X motif 17 (Nudix motif 17) (EC 3.6.1. )
  • Length: 328  
  • Mass: 35923
• Sequence:

  MAEVRVQLLLSRRPESVSFARSVCGLLGAGPGLGTWPIHCSLKRGRLVLSSRPFPGASARLPLQRPPFCPFAALE
  ERPRVPGAELPTDRGVDLGVAVILQSSDKTVLLTRRARTLSVSPNLWVPPGGHVELEEELLDGGLRELWEESGLH
  LPQGQFSWVPLGLWESAYPPRLSWGLPKYHHIVLYLLVISQESQQQLQARIQPNPNEVSALMWLTPDVAAAVAAA
  EDGTETPGLLPQDLPPSVLAVELEEDGRARPLVLHMSTLLRMIPTMAEDKERVSTGTKFALKLWLQHLGRTPPPC
  KSAAYLDPGPAKEEWNMDPLPPNQGSGK

• Structural information:
  • Protein Domains: (90..23-)
    (/note="Nudix-hydrolase)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00794"-)
  • Interpro: IPR015797  IPR000086  IPR033716  
  • Prosite: PS51462
  • CDD: cd04694
  • PDB: 5LF8
  • PDBsum: 5LF8
  • STRING: ENSP00000334437
• Other Databases: GeneCards:  NUDT17  Malacards:  NUDT17

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0016787	hydrolase activity	IBA	molecular function
GO:0006742	NADP catabolic process	IBA	biological process
GO:0006734	NADH metabolic process	IBA	biological process
GO:0005829	cytosol	IBA	cellular component
GO:0035529	NADH pyrophosphatase activity	IBA	molecular function
GO:0019677	NAD catabolic process	IBA	biological process
GO:0005777	peroxisome	IBA	cellular component
GO:0016787	hydrolase activity	IEA	molecular function
GO:0046872	metal ion binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function

Diseases

Associated diseases	References
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			19 (6 controls, 13 cases)	Male infertility	GSE6872 analyzed by GEO2R (cutoff 1.5 fold)