• Gene id: 1977

Gene Summary

• Gene Symbol: EIF4E   Gene   UCSC   Ensembl
• Aliases: AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
• Gene name: eukaryotic translation initiation factor 4E
• Alternate names: eukaryotic translation initiation factor 4E, eIF-4F 25 kDa subunit, eukaryotic translation initiation factor 4E-like 1, mRNA cap-binding protein,
• Gene location: 4q23 (98930636: 98871683)     Exons: 19     NC_000004.12
• Gene summary(Entrez): The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruit
• OMIM: 133440

Protein Summary

• Protein general information: P06730  
  • Name: Eukaryotic translation initiation factor 4E (eIF 4E) (eIF4E) (eIF 4F 25 kDa subunit) (mRNA cap binding protein)
  • Length: 217  
  • Mass: 25097
• Sequence:

  MATVEPETTPTPNPPTTEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWAL
  YNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVC
  GAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV

• Structural information:
  • Interpro: IPR023398  IPR001040  IPR019770  
  • Prosite: PS00813
  • PDB: 1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
  • PDBsum: 1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4BEA 4DT6 4DUM 4TPW 4TQB 4TQC 4UED 5EHC 5EI3 5EIR 5EKV 5GW6 5T46 5ZJY 5ZJZ 5ZK5 5ZK7 5ZK9 5ZML
  • DIP: 22
• Other Databases: GeneCards:  EIF4E  Malacards:  EIF4E

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0010507	negative regulation of autophagy	IMP	NOT|biological process
GO:0016281	eukaryotic translation initiation factor 4F complex	IBA	cellular component
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0000340	RNA 7-methylguanosine cap binding	IBA	molecular function
GO:0005829	cytosol	IDA	cellular component
GO:0000340	RNA 7-methylguanosine cap binding	IDA	molecular function
GO:0010494	cytoplasmic stress granule	IDA	cellular component
GO:0006417	regulation of translation	IDA	biological process
GO:0003743	translation initiation factor activity	IDA	molecular function
GO:0016281	eukaryotic translation initiation factor 4F complex	IDA	cellular component
GO:0005845	mRNA cap binding complex	IDA	cellular component
GO:0045931	positive regulation of mitotic cell cycle	IMP	biological process
GO:0000082	G1/S transition of mitotic cell cycle	IMP	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0003723	RNA binding	IEA	molecular function
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0006417	regulation of translation	IEA	biological process
GO:0005737	cytoplasm	IEA	cellular component
GO:0006413	translational initiation	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0016032	viral process	IEA	biological process
GO:0003743	translation initiation factor activity	TAS	molecular function
GO:0000339	RNA cap binding	TAS	molecular function
GO:0016281	eukaryotic translation initiation factor 4F complex	TAS	cellular component
GO:0000932	P-body	IDA	cellular component
GO:0016442	RISC complex	IDA	cellular component
GO:0031370	eukaryotic initiation factor 4G binding	IDA	molecular function
GO:0019899	enzyme binding	IDA	molecular function
GO:0070491	repressing transcription factor binding	IDA	molecular function
GO:0048471	perinuclear region of cytoplasm	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0006406	mRNA export from nucleus	TAS	biological process
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0006405	RNA export from nucleus	TAS	biological process
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0099524	postsynaptic cytosol	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005845	mRNA cap binding complex	IEA	cellular component
GO:0019827	stem cell population maintenance	IEA	biological process
GO:0033391	chromatoid body	IEA	cellular component
GO:0045182	translation regulator activity	IEA	molecular function
GO:0045665	negative regulation of neuron differentiation	IEA	biological process
GO:0071549	cellular response to dexamethasone stimulus	IEA	biological process
GO:0016281	eukaryotic translation initiation factor 4F complex	IEA	cellular component
GO:0030324	lung development	IEA	biological process
GO:0031370	eukaryotic initiation factor 4G binding	IEA	molecular function
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0001662	behavioral fear response	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0017148	negative regulation of translation	IEA	biological process
GO:0098978	glutamatergic synapse	IEA	cellular component
GO:0099578	regulation of translation at postsynapse, modulating synaptic transmission	IEA	biological process
GO:0032991	protein-containing complex	IEA	cellular component
GO:0098794	postsynapse	IEA	cellular component
GO:0031370	eukaryotic initiation factor 4G binding	IDA	molecular function
GO:0010494	cytoplasmic stress granule	IEA	cellular component
GO:0000932	P-body	IEA	cellular component
GO:0005737	cytoplasm	IEA	cellular component
GO:0005829	cytosol	IDA	cellular component
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA	cellular component
GO:0005737	cytoplasm	IDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003743	translation initiation factor activity	ISS	molecular function
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function

KEGG pathways

Pathway id	Pathway name
hsa04151	PI3K-Akt signaling pathway
hsa03013	RNA transport
hsa04150	mTOR signaling pathway
hsa04910	Insulin signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04211	Longevity regulating pathway
hsa01521	EGFR tyrosine kinase inhibitor resistance
P06959	CCKR signaling map
P06959	CCKR signaling map

Diseases

Associated diseases	References
Autism	KEGG:H02111
Autism	KEGG:H02111
Non obstructive azoospermia	MIK: 24012201
Sertoli cell only syndrome	MIK: 23869807
Spermatogenic defects	MIK: 31037746

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
24012201	Non obstructive azoospermia			31 (4 controls, 27 cases)	Male infertility	GSE45885 analyzed by GEO2R (cutoff 1.5 fold)
23869807	Non obstructive azoospermia, Sertoli cell only syndrome			20 (4 controls, 16 cases)	Male infertility	GSE45887 analyzed by GEO2R (cutoff 1.5 fold)
31037746	Spermatogenic defects			28 men with azoospermia	Male infertility	Microarray