• Gene id: 1973

Gene Summary

• Gene Symbol: EIF4A1   Gene   UCSC   Ensembl
• Aliases: DDX2A, EIF-4A, EIF4A, eIF-4A-I, eIF4A-I
• Gene name: eukaryotic translation initiation factor 4A1
• Alternate names: eukaryotic initiation factor 4A-I, ATP-dependent RNA helicase eIF4A-1, eukaryotic initiation factor 4AI, eukaryotic translation initiation factor 4A,
• Gene location: 17p13.1 (45688180: 45694437)     Exons: 3     NC_000001.11
• OMIM: 602641

Protein Summary

• Protein general information: P60842  
  • Name: Eukaryotic initiation factor 4A I (eIF 4A I) (eIF4A I) (EC 3.6.4.13) (ATP dependent RNA helicase eIF4A 1)
  • Length: 406  
  • Mass: 46154
• Sequence:

  MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQ
  AQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQME
  APHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTK
  KFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
  AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINM
  VTEEDKRTLRDIETFYNTSIEEMPLNVADLI

• Structural information:
  • Protein Domains: (63..23-)
    (/note="Helicase-ATP-binding)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00541-)
    (245..40-)
    (/note="Helicase-C-terminal)
    (/evidence="ECO:0000255|PROSITE-ProRule:PRU00542"-)
  • Interpro: IPR011545  IPR014001  IPR001650  IPR027417  IPR000629   IPR014014  
  • Prosite: PS00039 PS51192 PS51194 PS51195
  • PDB: 2G9N 2ZU6 3EIQ 5ZBZ 5ZC9
  • PDBsum: 2G9N 2ZU6 3EIQ 5ZBZ 5ZC9
  • DIP: 29755
  • STRING: ENSP00000293831
• Other Databases: GeneCards:  EIF4A1  Malacards:  EIF4A1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0003743	translation initiation factor activity	IBA	molecular function
GO:0002183	cytoplasmic translational initiation	IBA	biological process
GO:0003724	RNA helicase activity	IBA	molecular function
GO:0003723	RNA binding	IBA	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0003676	nucleic acid binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0016787	hydrolase activity	IEA	molecular function
GO:0006412	translation	IEA	biological process
GO:0003743	translation initiation factor activity	IEA	molecular function
GO:0004386	helicase activity	IEA	molecular function
GO:0006413	translational initiation	IEA	biological process
GO:0016032	viral process	IEA	biological process
GO:0003723	RNA binding	IEA	molecular function
GO:0000166	nucleotide binding	IEA	molecular function
GO:0005524	ATP binding	IEA	molecular function
GO:0003724	RNA helicase activity	IEA	molecular function
GO:0003725	double-stranded RNA binding	IDA	molecular function
GO:0006413	translational initiation	TAS	biological process
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005829	cytosol	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005515	protein binding	IPI	molecular function
GO:0005737	cytoplasm	IDA	cellular component
GO:0005634	nucleus	IDA	NOT|cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0070062	extracellular exosome	HDA	cellular component
GO:0003723	RNA binding	HDA	molecular function
GO:0016281	eukaryotic translation initiation factor 4F complex	TAS	cellular component
GO:0005515	protein binding	IPI	molecular function
GO:0000339	RNA cap binding	TAS	molecular function
GO:0003723	RNA binding	HDA	molecular function
GO:0016020	membrane	HDA	cellular component
GO:0008135	translation factor activity, RNA binding	TAS	molecular function
GO:0008135	translation factor activity, RNA binding	TAS	molecular function
GO:0004386	helicase activity	TAS	molecular function
GO:0003729	mRNA binding	TAS	molecular function

KEGG pathways

Pathway id	Pathway name
hsa03013	RNA transport

Diseases

Associated diseases	References
Hypospadias	MIK: 24778562
Teratozoospermia	MIK: 17327269

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes
17327269	Teratozoospermia			13 (5 controls, 8 cases)	Male infertility	GSE6967 analyzed by GEO2R (cutoff 1.5 fold)
24778562	Hypospadias			13 (5 controls, 8 cases)	Male infertility	Microarray